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題名 | Immunohistochemical Analyses of p53 Protein Expression in Breast Cancers in Taiwan: A Clinicopathologic Study=利用免疫組織染色法偵測臺灣乳癌病人p53蛋白質的表現:臨床病理之研究 |
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作者姓名(中文) | 朱娟秀; 李威傑; 張金堅; 許輝吉; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 96:4 1997.04[民86.04] |
頁次 | 頁237-241 |
分類號 | 416.226 |
關鍵詞 | 免疫組織染色法; 臺灣; 乳癌病人; p53蛋白質; Breast cancer; p53 protein expression; Immunohistochemistry; Protein expression; |
語文 | 英文(English) |
英文摘要 | Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients. All patients had a followup period of more than 5 years. Protein expression of p53 was detected in 64 patients (30.5%). There was significant correlation between p53 protein expression and a high histologic grade (grade III vs grade I/II, 49% vs 23.6%, p=0.0008) and high mitotic index (≧ 10/10 hpf vs < 10/10 hpf, 42.9% vs 19.6%, p=0.0004), but not with axillary node status, stromal lymphocytic infiltration, or estrogen receptor or progesterone receptor status. We found that p53 protein expression was not a significant factor in predicting 5-year mortality. |
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