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題名 | 病毒檢驗在腫瘤診斷與治療之的應用=Application of Viral Examinations in the Diagnosis and Therapy of Tumors |
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作者姓名(中文) | 周寬基; 張錦霞; 周絢蘭; 曾文瑟; 陳光耀; | 書刊名 | 放射治療與腫瘤學 |
卷期 | 4:2 1997.06[民86.06] |
頁次 | 頁155-178 |
分類號 | 415.138 |
關鍵詞 | 病毒; 腫瘤; 癌化作用; 腫瘤診斷; 治療; Tumor; Viruses; Carcinogenesis; Diagnosis; Treatment; |
語文 | 中文(Chinese) |
中文摘要 | 病毒與腫瘤的關係非常密切,首先是在 1908 年,由 Ellerman 和 Bang 氏所建 立。他們研究雞的白血病時,發現白血病雞的無細胞過濾萃取液能感染其他雞的白血病。之 後,更在其他動物如鼷鼠、貓、猿及人類身上陸續地發現可過濾的 " 腫瘤 DNA"。本文針對 病毒與腫瘤的關係、病毒與腫瘤之間關係建立的條件、與人類腫瘤有關的病毒 (包括反轉錄 病毒、肝炎病毒、乳突病毒、�秤l病毒 )、病毒在細胞內的癌化作用以及病毒在腫瘤診斷與 治療上的應用,分析已知病毒與腫瘤的研究。[ 放射治療與腫瘤學 1997;4: 155-178] |
英文摘要 | The close association between tumor and virus was established in 1908 by Ellerman and Bang when they observed that chicken leukemia could be transmitted through noncellular extract from the afflicted fowl. As a result, "tumor DNA" was successively identified in several other species, i.e., mouse, cat, monkey and human beings. In this report, we reviewed the relationship between virus and tmor, the criteria determining this relation, the virus-associated human tmors, the potential carcino-genic process of virus inside thecell, and the application of virus in the diagnosis and therapy of the tumor in human. We used Epstein-Barr virus as a model to explain the latent as well as acute infection in the carcinogenesis and the disease progression marker in human. We further extrapolated the observations from herpes-virus and retrovirus to interpret the interactions between the host genes and the viral genes in the conversion process from proto-oncogene to oncogene. Finally, we discussed the current status of application of viruses in tumor diagnosis and gene therapy. In conclusion, although virus has been closely associated with tumor, the consequential carcinogenic process between virus infection and tumor formation remains to be elucidated. [Therapeut Radiol Oncol 1997; 4: 155-178] |
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