查詢結果分析
相關文獻
- Safety and Immunogenicity of a Conjugated Haemophilus Influenzae Type B Polysaccharide-Heisseria Meningitidis Outer Membrane Protein Vaccine
- 臺灣地區A型肝炎流行之演變與疫苗的成效
- Vaccine Storage Practices in Primary Care Physicians' Offices in Taiwan
- Immunogenicity and Safety of Haemophilus Influenzae Type b Conjugate Vaccine (HibTITER) and a Combination Vaccine of Diphtheria, Tetanus, Pertussis and HibTITER (TETRAMUNE) in Two-Month-Old Infants
- 我國21世紀美國豬用疫苗研製方向的預測
- 臺灣疫苗的發展
- 臺灣地區嬰兒性別偏好之初步探討
- Immunogenicity of Oral Poliovirus Vaccine in Taiwan
- 臺灣本土型雞傳染性支氣管炎減毒疫苗保護效力之初步評估
- PRRS疫苗於臺灣之田間試驗報告
頁籤選單縮合
題名 | Safety and Immunogenicity of a Conjugated Haemophilus Influenzae Type B Polysaccharide-Heisseria Meningitidis Outer Membrane Protein Vaccine=B型流行感冒嗜血桿菌多醣質與腦膜炎球菌外膜蛋白結合疫苗在臺灣二至十四個月嬰兒使用效果評估 |
---|---|
作者 | 葉樹人; 黃立民; 陳中明; 李秉穎; 張鑾英; 林逸甄; 丘秀慧; 李慶雲; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 96:2 1997.02[民86.02] |
頁次 | 頁110-115 |
分類號 | 417.517 |
關鍵詞 | B型流行感冒; 腦膜炎球菌; 疫苗; 臺灣; 嬰兒; Vaccine; Conjugate; Taiwan; Immunization; Haemophilus influenzae type b; |
語文 | 英文(English) |
英文摘要 | This study was performed to determine the immunogenicity and safety of a conjugate Haemophilus influenzae type b (Hib) vaccine (PedvaxHIB ��;) Merck Sharp & Dohme Inc, West Point, PA, USA) in Taiwanese children. There were two groups in this study. Group A included 56 infants at 2 months of age, who received an initial dose of Hib conjugate vaccine at age 2 months and 4 months. Another booster dose was given between 12 and 15 months of age. Group B included 58 children, aged 11 to 14 months, who were vaccinated at the time of enrollment and 2 months after the first vaccination. The results showed that this Hib conjugate vaccine was highly immunogenic with 100 % and 86 % of vaccinees in group A developing anti-Hib polyribosylribitol phosphate (PRP) antibody titers above 0.15 μ g/mL and 1 μ g/mL, respectively, after two vaccinations. A slightly better response rate was observed in group B, with 100 % and 97 % of vaccinees developing antibody titers above 0.15 μ g/mL and 1 μ g/mL, respectively, after two vaccinations. A significant booster effect was seen in group A; the proportion of subjects with antibody titers above 1 μ g/mL increased from 38 % and 95 %, and the geometric mean titer increased from 0.68 μ g/mL to 11.92 μ g/mL. Adverse reactions were uncommon. Mild reactions consisted of low-grade fever and local discomfort. We conclude that the Hib conjugate vaccine is highly immunogenic and safe when given to Taiwanese children as young as 2 months of age. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。