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題名 | 雜環醌類之生理活性6-烷硫-7-胺基-及6-胺基-7-烷硫-5,8-喹啉酮之合成與抗生活性=Heteroquinones with Biological Activities: Synthesis and Antimicrobial Activities of 6-Alkyl Mercapto-7-Amino-and 6-Amino-7-Alkyl Mercapto-5,8-Quinolinequinone Derivatives |
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作者 | 林美香; 蕭超隆; 郭憲壽; | 書刊名 | 北醫學報 |
卷期 | 25:2 1996.12[民85.12] |
頁次 | 頁12-21 |
分類號 | 418.286 |
關鍵詞 | 喹啉酮; 抗生活性; 合成; Quinolinequinone; Antimicrobial; Synthesis; |
語文 | 中文(Chinese) |
中文摘要 | 合成一系列的6-烷硫-7-胺基(Va-i)和6-胺基-7-烷硫(VIIa,b)-5,8-□□酮及其抗生活性的探討;其中以6-丙硫基-7-七環胺(Vf),6-丁基硫-7-七環胺(Vi)和6-五環胺-7-丙基硫(VIIb)-5,8-□□酮對金黃色葡萄球菌(ATCC 33591)有相當好的抑制效果(MIC 0.3μg/ml),但對其它微生物之最低抑制濃度,則多超過100μg/ml。 |
英文摘要 | A series of 6-alkyl mercapto-7-amino(V□) and 7-alkyl mercapto-6-amino (VII□)-5,8-quinolinequinone were synthesized and evaluated for antimicrobial activities. Among the above 7-hexahydroazepino-6-propyl mercapto(V�� ), 7-hexahydroazepino-6-butyl mercapto(V�� ) and 7-propyl mercapto-6-pyrrolidino (VII�k )-5,8-quinolinequinone had surprisingly low MIC (0.3μg/ml) against Staphylococcus aureus ATCC 33591, whereas against other microorganisms preceded 100μg/ml. |
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