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題名 | Compatibility of Ticarcillin Disodium and Famotidinf in 5% Dextrose Injection=Ticaracillin Disodium及Famotidine於5%葡萄糖靜脈注射輸送液中配伍性之研究 |
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作者 | 嚴智譯; 王大鵬; 王孟廷; 黃志賢; Yen, Chih-i; Wang, Da-peng; Wang, Meng-ting; Wong, Chi-yin; |
期刊 | 醫學研究 |
出版日期 | 19961100 |
卷期 | 17:3 1996.11[民85.11] |
頁次 | 頁147-152 |
分類號 | 418.87 |
語文 | eng |
關鍵詞 | 5%葡萄糖靜脈注射輸送液; 儲存; 高壓液相層析儀; 配伍性; Ticarcillin disodium; Famotidine; Dextrose injectioin; Storage; HPLC; Compatibility; |
英文摘要 | The compatibility of ticarcillin disodium and famotidine in 5% dextrose injection stored at two temperature was studied. Ticarcillin disodium and famotidine were reconstituted and diluted with 5% dextrose injection to form an admixture with a famotidine concentration of 0.2 mg/ml and a ticarcillin concentration 10 mg/ml. The admixture was stored in 100-ml vented i.v. containers in the dark at 4℃ and 25℃; three containers were stored at each temperature. A 2-ml sample was taken from each container after 0.25, 1, 2, 5, 10, 24, 48, 72 and 96 hours of storage and visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for each storage condition. No color change or precipitation was observed in any sample at any time during the stability studies. More than 90% of the initial concentrations of both drugs remained for 72 hours at 4℃ but 24 hours at 25℃. Under the conditions of this study, ticarcillin disodium 10 mg/ml and famotidine 0.2 mg/ml in admixture in 5% dextrose injection are stable only 24 hours at 25℃ and 72 hours at 4℃. |
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