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題 名 | Change of Chemokines during Immunotherapy in Asthmatic Children=氣喘病患童接受減敏治療前後的趨化激素變化 |
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作 者 | 江伯倫; 呂鳳美; 莊雅惠; 周正成; 謝貴雄; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 37:5 民85.09-10 |
頁 次 | 頁324-332+387 |
分類號 | 417.5343 |
關鍵詞 | 趨化激素; 蟍; 免疫療法; Chemokine; Mite; Immunotherapy; |
語 文 | 英文(English) |
中文摘要 | 氣喘病在近年來有逐年增加的趨勢,而其中減敏治療被認爲是較有效果的一種方法。而在引起氣喘發作的諸多因子中以組織胺釋出因子(histamine releasing factor, HRF)爲最重要的一種,組織胺釋出因子能夠刺激嗜鹼性白血球/肥胖細胞釋出組織胺,但是到目前爲止組織胺釋出因子的成分仍不是很清楚。本研究便是進一步探討氣喘症患童接受減敏治療前後趨化激素變化的情形。我們是由六位氣喘症患童接受減敏治療前、四個月和八個月後抽血分離出周邊血液單核球,分別利用裂殖素和mite過敏原刺激培養,然後再取出上清液測定MGAF、MIP-la、RANTESt和IL-8的濃度。我們的結果顯示蟎MCAF和MIP-la的濃度在接受治療四個月後先上昇再下降;RANTES的值則呈現上昇;IL-8的值也是上昇。趨化激素的制造異常可能是導致氣喘發作的一個重要原因,所以進一步了解趨化激素在減敏治療前後和發病機轉中所扮演的角色將有助未來發展更新的治療方法。 |
英文摘要 | Histamine-releasing factor (HRF) consists of a group of cytokines that can cause basophil/mast cell to release histamine, however, the composition of HRF still remains undefined. This study was designed to measure the concentrations of chemokines in asthmatic children receiving immunotherapy. Peripheral blood mononuclear cells culture supernatants were obtained from six asthmatic children before and four, eight months after immunotherapy (IT). The levels of monocyte chemotactic and activating factor (MCAF), macrophage inflammatory protein-la (MIP-la), regulated on activation normal T-cell expressed and secreted (RANTES) and interleukin-8 (IL-8) spontaneously and after stimulation with PHA and mite allergen in the supernatants. The data showed: 1) The levels of MCAF and MIP-la increased four months, and decreased eight months, after IT; 2) By contrast, the level of RANTE increased after IT; 3) The level of IL-8 also tended to increase after lT. Abnormal chemokine production may contribute to the pathogenesis of bronchial asthma and restoration of normal chemokine production may be used to partially explain the clinical efficacy of immunotherapy. |
本系統中英文摘要資訊取自各篇刊載內容。