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題 名 | Ex Vivo Evidence of Platelet Activating Factor on Ischemic Liver Injury=以體外灌流模式證實血小板活化因子對缺血性肝傷害所扮演之角色 |
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作 者 | 王國新; | 書刊名 | 長庚醫學 |
卷 期 | 19:3 1996.09[民85.09] |
頁 次 | 頁229-234 |
分類號 | 415.533 |
關鍵詞 | 血小板活化因子; 體外灌流; 缺血性肝傷害; PAF; Platelet activating factor; Ischemic liver injury; Isolated liver perfusion; AST; Asparate aminotransferase; |
語 文 | 英文(English) |
中文摘要 | 自由基對於缺血性臟器的影響在最近頗受注目,由於血小板活化因子之參與其中,有關其對於臟器之缺血,尤其是肝臟方面很受外科醫師之關切。為防止在生體上受到種種因素的影響,我們使用大白鼠體外灌流的實驗模式。我們發現即使使用到超過生體負荷程度之血小板活化因子,再加上30或60分鐘的缺血,也不能造成或加重肝臟之傷害。由此可見,血小板活化因子本身並不足以造成傷害,生體循環中的其他因子及血液成份之共同作用,才是缺血性肝臟傷害發生的成因。 |
英文摘要 | Recently, platelet activating factor has attracted a lot of research interest due to its involvement in ischemia-reperfusion injury including ischemic liver injury. However, due to its propagating effect to cause systemic hypotension, the direct effect of platelet activating factor on the liver could not be demonstrated easily. In order to avoid the interference of other factors in vivo, ex vivo isolated rat liver perfusion system was applied in this study. Administration of platelet activating factor as high as 10[]M, which caused shock and death through intravenous injection, did not exacerbate ischemic injury of 30 or 60 mins ischemia with the perfusion model. These results show that platelet activating factor, unlike it dose in vivo, neither hurts hepatocyte nor exacerbates ischemic liver injury directly. It is suggested that the effect of platelet activating factor on ischemic liver injury may be operated through other factors, which are present with intact circulatory system and blood components, to exacerbate the ischemia-reperfusion injury on liver. |
本系統中英文摘要資訊取自各篇刊載內容。