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題 名 | 番椒晶素及SNA對人類血小板的抑制作用 |
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作 者 | 楊竹茂; 游慧美; 高惠珍; 傅利芳; | 書刊名 | 嘉南學報 |
卷 期 | 20 1994.11[民83.11] |
頁 次 | 頁204-220 |
分類號 | 418.2321 |
關鍵詞 | 番椒晶素; 抗血小板凝集活性; 膠原蛋白; 血小板活化因子; Capsaicin; Sdium nonivamide acatate; Anti-platelet activity; ADP; Collagen; PAF; SNA; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究旨在探討番椒晶素與合成的同類物SNA(Sodium Nonivamide Acetate)的抗血小板凝集作用之活性與機轉,由一系列實驗顯示:二者皆能抑制由 膠原蛋白所誘發之血小板凝集作用;番椒晶素顯示對綿羊精囊微粒體催化花生烯 酸產生前列腺素E�祠鉿陰j烈的抑制作用,然而SNA並無此作用;兩者對經 indomethacin處理與未處理之人體血小板微粒體(IPM)催化花生烯酸所產生的凝血 素B�祠膃鳥窄q相關性的抑制作用;兩者皆能抑制以螺旋條狀的兔主動脈所進行 的生物檢測法中,由IPM催化前列腺素內過氧化物產生凝血素B�祖漣@用。由以 上實驗結果顯示,SNA的抗血小板凝集的作用可能由於選擇性抑制人體血小板中 凝血素合成酵素的活性所導致。 |
英文摘要 | The aim of this study is to investigate the anti-platelet aggregation activities and the possiblemechanisms of action of capsaicin (CAP) and the synthetic analogue- SNA (Sodium NonivamideAcetate). The results obtained from a series of experiments demonstrated that both cmpounds inhibited the platelet aggregation induced by collagen; CAP also showed a strong inhibition onPCE2 formation from [�釮] A.A. by sheep seminal vesicle (SSV) microsomes, while SNA did nothave this effect. Both drugs produced a dose-dependent inhibition of TXB] formation from [�釮]A.A. by human platelet microsomes and from PG-endoperoxides by indomethacin-treated humanplatelet microsomes (lPM). In the bioassay with spiral strip of rabbit- aorta, both drugs inhibitedthe formation of TXAi-like from PG- eiidopcroxides by lPM. In conclusion, the anti-platelet effect of SNA might be due to the selective inhibition of thromboxane synthetase activity in human platelets. |
本系統中英文摘要資訊取自各篇刊載內容。