查詢結果分析
相關文獻
- 以氣相層析質譜方法及氘同位素藥物為內部標準品應用於定量尿液中安非他命之探討
- Evaluation of Isotopic Analogs as Internal Standard for Quantitative Determination of Urinary 6-Acetylmorphine by Gas Chromatography/Mass Spectrometry
- 國軍毒物中毒諮詢與鑑定之研究
- 比較以酵素免疫分析法及氣相層析質譜儀法測定安非他命及嗎啡準確性之研究
- 以氣相層析質譜儀分析甲基安非他命
- Detection of Abused Drugs in Urine by GC-MS
- 替代燃料對汽柴油引擎性能、毒性、污染與噪音特性分析之研究
- Clinical Manifestations and Prognostic Features of Acute Methamphetamine Intoxication
- 安非他命類藥物性質及其對犯罪行為影響分析
- 慢性安非他命處理對大白鼠行為的影響
頁籤選單縮合
題 名 | 以氣相層析質譜方法及氘同位素藥物為內部標準品應用於定量尿液中安非他命之探討=GC/MS Analysis of Amphetamine in Urine with Amphetamine-d邚(side chain) as an Internal Standard |
---|---|
作 者 | 王博譽; 戴世傑; 黃炳中; 劉瑞厚; 孫慈悌; | 書刊名 | 藥物食品分析 |
卷 期 | 4:2 1996.06[民85.06] |
頁 次 | 頁123-130 |
分類號 | 418.81 |
關鍵詞 | 安非他命; 氣相層析質譜儀; 衍生化試劑; Amphetamine; GC/MS; Derivative; |
語 文 | 中文(Chinese) |
英文摘要 | This study examined the accessibility of using amphetamine-d5 (side chain) as an internal standard in quantitative analysis of the trichloroacetyl derivative of urinary amphetamine by gas chromatography / mass spectrometry (GC/MS). In GC/MS analysis , fragments with minimal interference between the assay protocol and the internal standard were selected for quantitation. In the full-scan mode, no interference from TCA-amphetamine-d5, the trichloroacetyl derivative of amphetamine-d5, was observed for the fragments of trichloroacetylamphetamine (TCA-amphetamine) with m/z 190, 188, 118 and 91. On the other hand, no interference from TCA-amphetamine was indicated in fragments of m/z 196 and 123 of TCA-amphetamine-d5. In the selective ion monitoring mode (SIM), the interference between m/z 190, 188, 118 and 91 of TCA-amphetamine and m/z 196, 194 and 123 of TCA-amphetamine-d5 was minimal. The fragments of m/z 190 from TCA-amphetamine and m/z 194 from TCA-amphetamine-d5 were thus selected for quantitation of urinary amphetamine by SIM. Calibration graph derived from the ratio of relative intensity of m/z 190 to m/z 194 versus the concentration of urinary amphetamine was linear over the concentration range of 31.25 - 2000 ng/mL (n=7, SD=0.0357, r=0.9987). Amphetamine-d5 was demonstrated to be a suitable internal standard in quantitative analysis of the trichloroacetyl derived urinary amphetamine by SIM analysis with GC/MS. |
本系統中英文摘要資訊取自各篇刊載內容。