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頁籤選單縮合
| 題 名 | A Procedure for Weight and Model Selection in Assay Development=化驗方法發展中模型與權數之選取 |
|---|---|
| 作 者 | 林慧; 周賢忠; | 書刊名 | 藥物食品分析 |
| 卷 期 | 4:1 1996.03[民85.03] |
| 頁 次 | 頁1-12 |
| 分類號 | 418.4 |
| 關鍵詞 | 儀器刻劃; 標準曲線; 化驗確認; 變異; Calibration; Standard curve; Assay Validation; Weight selection; Model selection; |
| 語 文 | 英文(English) |
| 英文摘要 | The problem of weight and model selection for standard curve in the calibration of an instrument for assay development is considered. An instrument is usually calibrated by studying the relationship between a number of known standards and their corresponding responses. The relationship between known standards and their responses is usually described by a standard curve. Based on the established standard curve, an unknown sample can be determined. In practice, since the responses may have different variabilities at different known standards and the relatioship between the standards and their corresponding responses may not be linear, it is important to select an appropriate model with an appropriate weight in establishing a standard curve for obtaining an accurate and reliable assay result. In this paper, criteria for weight and model selection are proposed to choose an appropriate statistical model among five commonly used models with three different possible weights. An example concerning the validation of a plasma assay of a pharmaceutical compound is presented to illustrate the use of the proposed criteria. |
本系統中英文摘要資訊取自各篇刊載內容。