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題名 | The Effect of Cimetidine on Serum Acidic Markers and Helicobacter Pylori in Gastric Ulcer Subjects=胃潰瘍病例以泰胃美治療前後血清胃酸標記值變化: 幽門曲狀桿菌扮演之角色 |
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作者 | 李啟德; 張扶陽; 李壽東; Lee, Chi-te; Chang, Full-young; Lee, Shou-dong; |
期刊 | 中華醫學雜誌 |
出版日期 | 19960100 |
卷期 | 57:1 1996.01[民85.01] |
頁次 | 頁28-33 |
分類號 | 415.526 |
語文 | eng |
關鍵詞 | 胃激素; 胃潰瘍; 幽門曲狀桿菌; 第二型組織氨拮抗劑; 第一型胃蛋白原; Gastric ulcer; Gastrin; Helicobacter pylori; H[feaf]-receptor antagonist; Pepsinogen I; |
中文摘要 | 背景:探討胃潰瘍病例經泰胃美(第二型組織氨拮抗劑)治療後,血清胃酸標記值之變化,及幽門曲狀桿菌對此變化之影響。 方法:共有四十八位經內視鏡及病理切片診斷為胃潰瘍患者進入本研究。幽門曲狀桿菌之感染由快速尿素測試或組織學確定。病患分別於泰胃美治療前後接受空腹血清胃激素及第一型胃蛋白原濃度之測定。泰胃美治療為期八週,每日四次,每次二百毫克。 結果:胃潰瘍之癒合率為百分之七十五。四十二位感染幽門曲狀桿菌之病患,僅三位轉為陰性。我們發現,血清胃激素濃度於感染幽門曲狀桿菌病患中,呈現有意義的上升(86.3+/-2.2pg/mlvs.103.1+/-4.3pg/ml,p<0.05),而未感染者並無此現象。相較之下,血清第一型胃蛋白原濃度於治療前後並無差異(91.5+/-6.6ng/mlvs.95.6+/-3.8ng/ml,NS)。 結論:泰胃美雖然對胃潰瘍之癒合效果不錯,卻無法根除幽門曲狀桿菌。泰胃美治療後,可見血清胃激素濃度明顯之上升,特別是在幽門曲狀桿菌感染之患者;而血清第一型胃蛋白原濃度則不受影響。 |
英文摘要 | Background: This study was conducted to investigate the influence of cimetidine on the Helilcobacter pylori (HP) colonization and serum acidic markers in gastric ulcer patients. Methods: Forty-eight patients with gastric ulcer confirmed by endoscopy were consecutively enrolled. HP colonization was confirmed by either urease test or histological examination. Fasting serum gastrin and pepsinogen I (PGI) levels were measured before and after 8 weeks of cimetidine treatment. Results: Healing of ulcer at the end of treatment was 75%. Initially, the infection rate of HP was 87.5% (42/48). After 8 weeks of treatment, HP clearance rate was only 7.1% (3/42). A significant elevation of serum gastrin level was seen in HP positive subjects after treatment (86.3 +/- 22.2 pg/ml vs. 103.1 +/- 44.36 pg/ml, p < 0,05) while HP negative patients did not show the effect. There was no significant change in the mean serum PGI concentration before and after cimetidine treatment (91.5 +/- 36.6 ng/ml vs. 95.6 +/- 43.8 ng/ml, NS). Conclusions: Cimetidine is not able to clear HP despite its good efficacy in healing gastric ulcers. HP should play an important role in the elevation of serum gastrin levels during cimetidine therapy while serum PGI levels are not influenced by the antisecretory ability of cimetidine. |
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