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| 題 名 | Dietary Manipulation on Plasma Prostanoids in Pigs=日糧脂肪酸對仔豬血中類前列素Prostacyclin及類前凝素Thromboxane生成之調節作用 |
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| 作 者 | 莊秀琪; 陳申君; 郭忠政; | 書刊名 | 中華農學會報 |
| 卷 期 | 172 1995.12[民84.12] |
| 頁 次 | 頁129-138 |
| 分類號 | 437.656 |
| 關鍵詞 | 類前列素; 類前凝素; 脂肪酸; 仔豬; Prostanoids; Dietary fatty acids; Piglets; |
| 語 文 | 英文(English) |
| 中文摘要 | 發炎介質,包括類癌列素PGI₂及類前凝素TXA₂等為多不飽和脂肪酸代謝之衍生物。PGI₂與TXA₂之間的平衡與相互拮抗的作用,與心血管疾病之成因,有密不可分的關係,PGI₂抑制血小板凝集作用,TXA₂則可促使血小板凝集。本實驗即以仔豬為動物模式,探討日糧中不同脂肪酸組成,對血中PGI₂與TXA₂生成量之影響。24頭離乳仔豬,隨機分配至4個飼養組,分別餵以含3%不同油脂之日糧,分別為大豆油、椰子油、魚油及豬油,餵飼期為28日。於餵飼期前後分別採血,檢驗血中的PGI₂及TXA₂含量,並分析日糧及體脂肪之脂肪酸組成。實驗結果顯示日糧脂肪酸組成可改變動物體脂肪之脂肪酸組成,椰子油組仔豬之中鏈脂肪酸含量顯著地高於其他3組;而魚油組仔豬含較多n-3多不飽和脂肪酸;大豆油組仔豬之亞麻油酸及花生油酸含量,皆顯著地高於其他3組;豬油組仔豬之飽和脂肪酸雖略高於其他3組,但差異並不顯著。4組仔豬血中PGI₂及TXA₂的濃度於飼養期前、後及其間之改變量,雖於統計上無顯著的差異,然大豆油組仔豬血中PGI₂及TXA₂含量均高於他組,豬油組次之,大豆油組血中PGI₂及TXA₂之總含量,顯著地高於魚油組。此結果顯示大豆油含大量的亞麻油酸,可改變仔豬體脂肪之脂肪酸組成,並生成較多的花生油酸,而花生油酸為主要的發炎介質PGI₂及TXA₂之代謝先驅物,故可能增加此類發炎介質之產生;魚油中的n-3脂肪酸,則可抑制PGI₂及TXA₂的生成。然而,實驗結果顯示中鏈脂肪酸對此類發炎物質之生成作用之影響,與n-3脂肪酸有相似的生化效應,而是否中鏈脂肪酸對此類發炎物質之生成,具有調節作用,則有待更深入的探討。 |
| 英文摘要 | This study was conducted to investigate the effects of dietary fatty acids on plasma prostanoids in piglets. Four diets containing different oils, soybean oil (S), lard (L), coconut oil (C), or fish oil (F) were used to feed the weaning pigs for 28 days. Before and after feeding the oils, venous blood was withdrawn from each piglet and the levels of PGI₂ and TXA₂ in plasma were examined by measuring their stable metabolites, 6-keto-PGF1 α and TXB₂, respectively. From the fatty acid profile, it was showed that dietary fatty acid composition may manipulate the fatty acid composition of abdominal fat in piglets. The plasma levels of 6-keto-PGF1 α and TXB₂ before and after feeding the different oil were not statistically different between groups. However, the highest levels of 6-keto-PGF1 α and TXB₂ were found in feeding S, then followed by feeding L. Total amount of plasma prostanoids in S group was significantly higher than that in feeding F. This results revealed that feeding 3% soybean oil can increase the incorporation of linoleic acid into membrane lipids, which can be converted into arachidonic acid, the major precursor of prostanoids, and thus may increase the synthesis of prostanoids. |
本系統中英文摘要資訊取自各篇刊載內容。