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| 題 名 | Clinical Evaluation of the Efficacy, Safety and Tolerance of Intramuscularly Administered Imipenem/cilastatin in Patients with Mild to Severe Infections=以肌肉注射Imipenem/cilastatin治療輕度至重度感染症的臨床評估 |
|---|---|
| 作 者 | 楊祖光; 許國忠; 周明淵; | 書刊名 | 醫學研究 |
| 卷 期 | 16:1 1995.07[民84.07] |
| 頁 次 | 頁19-24 |
| 分類號 | 418.284 |
| 關鍵詞 | 有效性; 安全性; 耐受性; 感染症; Efficacy; Safety; Tolerance; Infections; |
| 語 文 | 英文(English) |
| 中文摘要 | 本計劃是評估以肌肉注射Imipenem/cilastatin治療輕度至重度感染症的有效性,安全性及耐受性。Imipenem/cilastatin的劑量是500毫克每天兩次。所有的病人都經過臨床及細菌學的評估。百分之九十五的病人達到臨床上痊癒及細菌學上根除的療效。肝功能及腎功能異常分別在兩個病人身上發現,但並無任何病人因此需停止治療。僅有兩個病人曾抱怨注射部位輕微且可忍受的疼痛。因此我們總結,肌肉注射Imipenem/cilastatin治療感染症是安全的,易耐受的及有效的。 |
| 英文摘要 | The efficacy and safety of intramusular injection of imipenem/cilastatin was studied in 30 patients with mild to severe bacterial infections. Twenty patients were evaluable for bacteriological efficacy; in the other ten patients no pathogens were isolated. Doses of imipenem/cilastatin was 500mg twice daily. All patients were evaluated clinically and bacteriologically. Clinical cure and bacteriological elimination was achieved in 95% of patients. Abnormal liver transaminases and renal functions were recorded in 2 (10%) and 2(10%) patients respectively. No patient was discontinued imipenem/cilastatin due to adverse effects. Only two patients experienced pain on injectjion sites and tenderness which were tolerable. It is concluded that intramuscular imipenem/cilastatin in these patients was well tolerated and efficacious. |
本系統中英文摘要資訊取自各篇刊載內容。