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題名 | Immunogenicity of An Inactivated Hepatitis A Vaccine in Healthy Children: Two Years' Follow-Up=於健康兒童接種非活化A型肝炎疫苗所產生之免疫力:兩年追蹤結果 |
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作者姓名(中文) | 李旺祚; 張美惠; 李慶雲; 陳定信; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 36:5 民84.09-10 |
頁次 | 頁331-335+387 |
分類號 | 412.58 |
關鍵詞 | A型肝炎疫苗; 兒童; 免疫性; Hepatitis A vaccine; Children; Immunogenicity; |
語文 | 英文(English) |
中文摘要 | 爲了研究非活化A型肝炎疫苗接種於兒童的長期免疫性,我們對一百位1至7歲缺乏A型肝炎抗體的健康兒童進行下列的研究。這些兒童分別接種三劑效價爲360 ELISA單位的HM 175株A型肝炎疫苗。接種的時間爲0,1和6個月。我們於接種第一劑之前和接種之後的第1,6,7,12和24個月,分別抽血測其A型肝炎的抗體和肝功能指數。A型肝炎抗體的測定是採用放射免疫定性法(RIA)和ELISA法。所有的兒童在接種兩劑疫苗後,於第6個月所測定的抗體皆呈陽性反應。除一男孩外,其它99位兒童的抗體在第24個月時仍呈陽性反應,且其抗體的幾何平均效價高達1,148mIV/Ml。在追蹤的兩年間,女性的抗體效價明顯高於男性。本研究顯示,非活化A型肝炎疫苗對於7歲以下的兒童是一種既安全又具免疫性的疫苗;疫苗所産生的抗體在99%的接種者可持續至少兩年,所以它是一種值得推廣的疫苗。 |
英文摘要 | To investigate the long-term immunogenicity of an inactivated hepatitis A vaccine in children, 100 healthy children, aged between I and 7 years old and all lacking the antibody to hepatitis A (HA) virus, were enrolled in this trial. The), received 3 doses of strain HM 175HA vaccine with 360 enzyme-linked immunosorbent assay (ELISA) units at 0, 1 and 6 months, respectively. Blood sampling for antibody and aminotransferases was performed 7 days before, then 1, 6, 7, 12, and 24 months after the first dose. The titers of antibody to HA virus were tested by radioimmunoassay and ELISA methods. All subjects became ELISA seropositive at Month 6 after two doses of vaccine. Except for one boy, 99 remained seropositive at Month 24, with a geometric mean titer of 1,148mIU/ml. Antibody titers for females were significantly higher than those for males throughout the follow-up period. It was concluded that the inactivated HA vaccine used in the present trial was immunogenic and safe in children below seven years old. The vaccine-induced antibody persisted for at least two years in 99% of the vaccines. |
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