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頁籤選單縮合
題 名 | Immunohistochemical Localization of Endothelin-Converting Enzyme-1 in Neuroendocrine Tumors and Normal Human Tissue=以免疫組織化學染色法定位伸經內分泌腫瘤及正常人類組織之內皮素轉化酵素-1 |
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作 者 | 許永祥; 黃士哲; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:11 2003.11[民92.11] |
頁 次 | 頁555-562 |
分類號 | 414.82 |
關鍵詞 | 內皮素; 內皮素轉化酵素-1; 神經內分泌腫瘤; Endothelin; ECE-1; Neuroendocrine tumor; |
語 文 | 英文(English) |
中文摘要 | 內皮素轉化酵素-1是內皮素合成中主要酵素,主要功能是參與內皮素大分子最後分解過程。本研究我們以抗原重現免疫組織化學染色法偵測 19 個正常組織及 16 個神經內分泌腫瘤之內皮素轉化酵素-1 分佈情況。結果顯示內皮素轉化酵素-1 主要分佈在血管內皮細胞及大部份上皮、腺體和腺管,包括食道、胃、小腸、盲腸、大腸、肝臟、膽囊、胰臟、子宮內膜、子宮頸、乳房、皮膚、攝護腺、膀胱、肺臟、腎臟、交感神經節、甲狀腺和腎上腺。最有趣的是內皮素轉化酵素-1 在神經內分泌細胞均有表達,同時所有 16 個神經內分泌腫瘤包括 3 例副交感神經瘤,5 例嗜鉻細部瘤,3 例類癌,4 例甲狀腺髓質癌和 1 例胰臟蘭氏小島細胞瘤亦有表達。結論:神經內分泌細胞及腫瘤內含有豐富內皮素轉化酵素-1,推測內皮素轉化酵素-1 在神經內分泌系統之生物活性上佔有重要角色。 |
英文摘要 | Endothelin-converting enzyme-1 (ECE-1) is the key enzyme of endothelin biosynthesis, catalyzing the final step in the process. In this study, we investigated the cellular distribution of ECE-1 in 19 normal human tissues and 16 neuroendocrine tumors using immunohistochemical staining with antigen retrieval. ECE-1 was expressed in vessel endothelial cells as well as nearly all epithelial cells, glands and duct cells in normal human tissues including the esophagus, stomach, small intestine, appendix, colon, liver, gallbladder, pancreas, endometrium, cervix, breast, skin, prostate, urinary bladder, lung, kidney, sympathetic ganglion, thyroid gland, and adrenal gland. The most interesting finding was that ECE-1 was expressed in normal neuroendocrine cells. ECE-1 was also expressed in all 16 neuroendocrine tumors, including three paragangliomas, five pheochromocytomas, three carcinoid tumors, four medullary carcinomas of the thyroid, and one islet cell tumor of the pancreas. In conclusion, ECE-1 is enriched in neuroendocrine cells and neuroendocrine tumors, suggesting an important biologic role for the enzyme in the neuroendocrine system. |
本系統中英文摘要資訊取自各篇刊載內容。