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| 題 名 | Photodynamic Effect on Breast and Colon Cancer Cells of Use of Merocyanine 540 as a Photosensitizer=使用Merocyanine 540 之光動力療法對乳癌及大腸癌細胞的效果 |
|---|---|
| 作 者 | 黃俊升; 黃實宏; 林宗義; 張金堅; | 書刊名 | 中華民國外科醫學會雜誌 |
| 卷 期 | 28:4 民84.07-08 |
| 頁 次 | 頁280-284 |
| 分類號 | 418.99 |
| 關鍵詞 | 光動力療法; 乳癌; 大腸癌; 細胞; kPhotodynamic therapy; Breast; Colon; Cancer; Merocyanine 540; |
| 語 文 | 英文(English) |
| 中文摘要 | 光動力療法是近來發展的治癌方法。此種方法藉著光來激發特定藥物,以產生殺死癌細胞的化學因子。本研究即觀察merocyanine 540 ( MC540 ) 對乳癌及大腸癌細胞的效果。吾人將不同劑量的MC540加入BCMl (乳癌細胞)及COL205(大腸癌細胞)的培養中,並將所有細胞分成兩組:一組接受光照射,一組置於黑暗中。實驗顯示:MC540 併照光組可抑制99%的乳癌及大腸癌細胞。而不照光組只抑制52%的乳癌細胞及84%的大腸癌細胞。其抑制作用或許因為MC54。在操作過程中,已先經光激發而產生。上述結果顯示以MC540為主的光動力療法,具有治療乳癌及大腸癌的作用,值得進一步研究。 |
| 英文摘要 | Photodynamic therapy is a newly-developed method for treating malignant tumors. It uses photodynamic dyes which can be activated by light, a process called "photosensitization", to produce cytotoxic agents. In this study a photosensitizer, merocyanine 540 (MC540), was applied to breast cancer and colon cancer cells. Variable doses of MC540 were added to BCM1, a breast cancer cell line and to COL205, a colon cancer cell line. Cells were divided into two groups: one group of cells was exposed to fluorescent light; the other group was kept in the dark. Treatment with MC540 plus light irradiation resulted in 99% inhibition of breast cancer and colon cancercell growth; while 52% inhibition was achieved in BCM1 and 84%inhibition in COL205 by MC540 alone without light irradiation. Results presented here show that in vitro photodynamic effect with MC540 is useful in treating breast cancer and colon cancer cells. This approach is worth further investigation. |
本系統中英文摘要資訊取自各篇刊載內容。