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頁籤選單縮合
題名 | Induction of Antigen-Specific Immunosuppression in Jirds with Early Stage of Brugia pahangi Infection=Brugia pahangi 誘發早期感染沙鼠產生抗原特異性免疫抑制 |
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作者 | 林大盛; | 書刊名 | 國立臺灣大學農學院研究報告 |
卷期 | 34:4 1994.12[民83.12] |
頁次 | 頁349-359 |
分類號 | 437.245 |
關鍵詞 | 抗原; 免疫抑制; 沙鼠; 絲蟲; 尼龍絲; 脾細胞; 調節細胞; 抑制細胞; Antigen; Brugia pahangi; Immunosuppression; Jird; Filaria; Nylon wool; Spleen cell; Regulatory cell; Suppressor cell; |
語文 | 英文(English) |
中文摘要 | 前面的研究指出,沙鼠細胞在感染Brugia pahangi絲蟲後第七天對抗原反 應上升,但在第十四天又下降,此種在感染早期所誘發之低反應狀態,不僅有利 感染仔蟲之生存,同時也有助於絲蟲之再次感染。以前曾經報導,B. pahangi可誘 發慢性感染沙鼠之脾臟,產生對尼龍絲有附著力之抗原特異性調節抑制細胞,但 淋巴結細胞卻仍然對抗原有反應。因此,本實驗利用細胞混合法及尼龍絲細胞分 離法,來求証是否有調節脾細胞參與沙鼠感染B. pahangi二週內之低反應狀態。結 果和前人研究一致,第十四天感染之脾細胞可抑制慢性感染沙鼠之淋巴結細胞對 抗原之反應:同時尼龍絲分離實驗結果亦指出,在感染二週內有附著性之抗原特 異性調節細胞產生。目前,有証據支持絲蟲感染主要促進第二型幫助細胞反應。 因此,繼續探討在此實驗發現的對尼龍絲有附著性之調節細胞,和第二型幫助細 胞之關係,將是個有趣的題目。 |
英文摘要 | Previous study has shown that the cellular responses to Brugiapahangi antigens increase on day 7 post-infection but diminish by 14days post-infection. This hypo-responsiveness status induced in theearly stage of infection not only favors the survival of the infectivelarvae but also enhances repeated filarial infections. It has beenreported that jirds chronically infected with B. pahangi have nylonwool adherent, antigen-specific regulatory (suppressor) cells foundpredominantly in spleen while lymph node cells still respond toantigens. Therefore, in the present study, the possibility of theinvolvement of regulatory spleen cells in the depressed responseobserved in jirds during the 14 days of infection with B. pahangi wasexamined by the experiments of mixed cell assay and nylon woolfractionation. In consistent with the previous work on chronicallyinfected animals, the result indicated that the antigenic response oflymph node cells from B. pahangichronically infected jirds wassignificantly suppressed by spleen cells from jirds 14 dayspost-infection. In addition, the results of nylon wool fractionationsuggested the presence of adherent antigen-specific regulatory cellsby 2 weeks of B. pahangi infection. It is now evident that filarialinfections promote a dominant T helper type 2 cell response.Therefore, it will be interesting to further investigate if there is anyrelationship between nylon wool adherent regulatory cells found inthis study and T helper type 2 cells. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。