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題 名 | 尿液黃麴毒素代謝產物和肝細胞癌之重疊病例對照研究=Urinary Aflatoxin Metabolites and Hepatocellular Carcinoma-A Nested Case-Control Study |
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作 者 | 連如蘋; 于明暉; 廖運範; 陳建仁; | 書刊名 | 中華公共衛生雜誌 |
卷 期 | 16:5 1997.10[民86.10] |
頁 次 | 頁417-427 |
分類號 | 415.5362 |
關鍵詞 | 黃麴毒素; 肝細胞癌; 重疊病例對照研究; Aflatoxin; Hepatocellular carcinoma; Nested case-control study; |
語 文 | 中文(Chinese) |
中文摘要 | 為探討臺灣地區黃麴毒素暴露和肝細胞癌發生的關係,本研究係以民國77-81年收 案自公保健診中心和長庚醫院肝病中心的 4841 名男性 B 型肝炎病毒帶原者和 Z501 名男 性非帶原者為研究世代,利用追蹤期間發生肝細胞癌且有庫存尿液檢體的 43 個案為病例組 , 每名病例選取一名 B 型肝炎表面抗原 (HBsAg) 陽性及一名 HBsAg 陰性未罹患肝細胞癌 個案為對照組。 研究結果顯示, 尿液黃麴毒素代謝產物間的相關性在肝細胞癌病例組, HBsAg 陽性對照組及 HBsAg 陰性對照組不同, 且各種尿液代謝產物佔黃麴毒素總量的百分 比在三組中亦有差異,AFM �� % 在 HBsAg 陰性對照組最高,AFP �� % 在 HBsAg 陰性對照 組最低,AFB �� % 在病例組最高。 黃麴毒素總量及大多數代謝產物濃度愈高,罹患肝細胞 癌的相對危險性愈高,在控制了其它重要危險因子作用後,尿液黃麴毒素總量及黃麴毒素 M �� (AFM �� ) 和罹患肝細胞癌的危險性有相關。 AFM �筒M肝細胞癌的相對危險性在不抽菸 、不喝酒、或年齡 50 歲以下者較高。 |
英文摘要 | In order to elucidate the association between aflatoxin exposure and hepatocellular carcinoma (HCC), a cohort of 4841 male asymptomatic chronic hepatitis B virus (HBV) carriers and 2501 male non-carriers aged 30 years or above was recruited from Govern- ment Employees Central Clinics and the Liver Unit of Chung-Gung Memorial Hospital between August, 1988 and June, 1992. There were 43 newly-developed HCC cases identified during follow-up periods. For each case, one HBV carrier and one HBV non-carrier were randomly selected as controls from cohort members without HCC. Cases and controls were matched with respect to age (within 3 years) and the Season of urine collection. Correlation among Vatious urinary aflatoxin metabolites were quite different for HCC cases, chronic HBV carriers, and HBV non-carriers. The relative risk of developing HCC was increased with uritary levels of total aflatoxins, aflatoxin P ��, afla- toxin M ��, aflatoxin-N �� -guanine, and aflatoxin B ��. After adjusting for other risk factors, uritary level of total aflatoxins and aflatoxin M �� were associated with the development of HCC. The relative risks of HCC associated with urinary aflatoxin M �� were more marked among individuals aged less than 50 years and those who smoked or drunk. |
本系統中英文摘要資訊取自各篇刊載內容。