查詢結果分析
相關文獻
- 卵磷脂對低學習性小白鼠之學習及神經傳達物質之影響作用
- 大豆卵磷脂增補對羽球選手生理反應與運動表現之影響
- 卵磷脂之代謝能值及影響其促進肉雞對脂肪消化率之因子--脂肪種類及年齡
- 核酸混合物對小白鼠學習記憶能力之影響
- 大豆卵磷脂在食品工業上的應用
- 蛋黃卵磷脂對於高血脂傾向大白鼠血脂質及肝脂質之影響研究
- 不同的血清或培養液對小白鼠胚胎生體外發育的比較
- Protective Effects of Partially Purified Antigens of Actinobacillus Pleuropneumoniae on Experimentally Infected Mice
- Effect of Dietary Protein Level on Passive Avoidance Performance and Brain Amino Acids in Senescence-Accelerated Mice
- 由花生油與玉米油之沉澱膠質物中分離粗卵磷脂及其物理化學特性之探討
頁籤選單縮合
題名 | 卵磷脂對低學習性小白鼠之學習及神經傳達物質之影響作用 |
---|---|
作者姓名(中文) | 鐘淑英; 鍾惠美; 王銘富; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 20:1 1995.01[民84.01] |
頁次 | 頁35-47 |
分類號 | 411.38 |
關鍵詞 | 阿耳滋海默氏病; 小白鼠; 乙醯膽鹼; 卵磷脂; 學習與記憶; Alzheimer's disease; Mice; Acetylcholine; Lecithin; Learning and memory; |
語文 | 中文(Chinese) |
中文摘要 | 本研究使用低學習性小白鼠作為阿耳滋海默氏病(Aizheimer's disease)的動物實驗模型。為求改善此低學習性小白鼠的學習能力,乃強制餵與100mg卵磷脂(lecithin),且添加維生素B12於卵磷脂中。四週後以被動逃避試驗法(passiveavoidancevtest測定其學習及記億能力,八週後再以HPLC-ED測定腦內三個部位之acetylcholine(ACh)及choline(Ch)濃度。結果得知卵磷脂能改善其學習和記憶如(0.05),在第八至十次測試時達成率約是88-94。同時分析卵磷脂給與後,正常鼠的Ch濃度皆增加約4-5倍,但是ACh濃度則不增加;低學習性小白鼠的海馬及線狀體ch濃度增加約1.2-1.5倍,海馬的ACh濃度亦顯著增加約等於控制組正常鼠的程度。雖然卵磷脂投與後有顯著改善此低學習性小白鼠的學習記憶及增加其腦內Ch和ACh濃度,但也可能是維生素B12的作用,則須進一步研究得知腦中膽鹼轉乙醯�t(choline acetyltransferase, ChAT)的活性。 |
英文摘要 | Poor-learning mice were used as the model animal to study the Aizheimer's disease. They were force-fed 100 mg lecithin together with vitamin B12.Passive avoidance test was conducted after four weeks of feeding to determinetheir learning and memory capability. HPLC-ED was used to measure theamount of acetylcholine (ACh) and choline (Ch) left at three different positions inthe brain after eight weeks. Results showed that the learning and memory capability of poor-learning mice were improved (p<0.05) with the lecithin supplementation, successful rate of 88-94 was observed. The Ch concentration of normalmice raised up to 4-5 times, while ACh concentration remained the same. In thepoor-learning mice, the Ch concentration increased about 20-50, whereas the ACh concentration increased markedly and nearly equal to that of normal mice. The role of vitamin B12 in improving the learning ability of poor-learning miceneed further investigation. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。