查詢結果分析
相關文獻
- 膽管結紮鼠膽管與腸管之再通作用
- Biochemical Events Associated with Ligation of the Common Bile Duct in Wistar Rats
- Plasmatic Changes of 5'-Nucleotidase, Alkaline Phosphodiesterase I and Secretory Component in Rats Early After Bile Duct Ligation
- Plasmatic changes of 5-nucleotidase, alkaline phosphodiesterase I and secretory component in rats early after bile duct ligation
- Pathologic Changes of Rat Liver After Bile Duct Ligation
- Xiao-Chai-Hu-Tang Attenuated the Expression of Proliferating Cell Nuclear Antigen and Epidermal Growth Factor in a Rat Model of Hepatic Fibrosis
- Liver Histologic Changes in Bile Ligated Rats
- The Effect of Bile Duct Ligation and Aflatoxin Administration on Alkaline Phosphatase and its Isozymes
- 燒傷病患增生性疤痕的復健護理
- Histomorphometric Evaluation of Mucin Content in Stone-Containing Intrahepatic Bile Ducts
頁籤選單縮合
| 題 名 | 膽管結紮鼠膽管與腸管之再通作用 |
|---|---|
| 作 者 | 陳三多; | 書刊名 | 臺灣畜牧獸醫學會會報 |
| 卷 期 | 64 1994.12[民83.12] |
| 頁 次 | 頁91-100 |
| 分類號 | 381.21 |
| 關鍵詞 | 膽管; 結紮; 增生; 小管再生; Bile duct; Ligation; Regeneration; Recanalization; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 結紮大白鼠的膽管已被廣泛應用於肝外阻塞性黃疸的研究。經膽管結紮的大白 鼠,雖然在結紮後會產生各種症狀以及肝臟之病變,但經一個月後,許多大白鼠仍不會死亡, 甚至外觀上,似乎已恢復正常。有關結紮後之病理變化,已有許多詳細之研究報告,但結紮 後,大白鼠如何存活或恢復正常,則無任何報告。 本實驗以大白鼠為實驗動物,分別進行短期及長期之膽管結紮,再定期予以犧牲,分別 檢查血清中之ALT, AST, ALP, GGT, GHOL 及 TBIL之變化,同時以組織切片檢查肝臟及膽管 之變化,並以組織化學染色法檢查膽管增生之情形,並以電子顯微鏡觀察肝細胞及膽管上皮 細胞之變化,以瞭解膽管結紮鼠存活或恢復之原因。 實驗結果顯示,老鼠經膽管結紮後,血清中ALT, AST, ALP, GGT, GHOL 及 TBIL於1 天後均急劇的升高,但7天後即下降至接近正常值,以後一直維持正常至105天以上,解剖 時,自第7天起即可發現結紮處近肝端之膽管明顯擴張,時間越久,擴張越厲害,以色素注 射入此膨大之膽管,結果可達至小腸,組織病理切片檢查於第1天後即可發現肝組織局部性 壞死,門脈區水腫及炎症細胞浸潤,第7天後,肝實質組織可見膽管增生,膨大的膽管壁發 生上皮內凹現象,第14天以後,腸繫膜上有膽管增生,於第42天後之標本,則見到膽管再 生入腸管內,至第105天時可見很多肝細胞呈變性變化,門脈三角區結締組織增生,膽管也 增多,結構呈不規則狀。 以電子顯微鏡檢查,在肝細胞可見到各種病變,包括粒線體腫大,核靠邊,粗內質網擴 張,脂肪小滴增加,甚至細胞質溶解,整個細胞壞死等,膽管系統在早期可見微膽管擴張, 微絨毛消失,後期則變化反而不明顯,膽管上皮細胞則無明顯之病變。 由此實驗的結果推論,老鼠經長期膽管結紮仍能存活的原因,是藉膽管擴張及增生,並 再穿入腸管形成新的膽汁輸送管而恢復正常。 # 330 1$aBile duct ligation is a very useful experimental model to study the extra-hepatic jaundice. Although the bile ductligated rats showed many clinical signs and hepatic lesions, however, most of them can survive and recover to normal. The pathologic changes after bile duct ligation had been detailly described in many papers, but, the mechanism of surviving has not mentioned yet. Therefore, in this study, not only the pathologic changes of bile duct ligation but the possible reasons of survival were detailly studied. After bile duct ligation, the ALT, AST, ALP, GGT, GHOL and TBIL were promptly increased at the first day, but declined gradually to normal after day 7, and persisted till day 105. The proximal-end bile duct of 7 days ligated rats was severely dilated. By histopathologic examination, many changes were found in the liver, mesentery and intestine, including, coagulative necrosis of hepatocytes, edema and inflammatory cells infiltration in portal triad, bile duct regeneration, extrahepatic bile duct epithelium invaginated into submucosa to form some new glandular structure, bile duct regenerated in mesentery, fibrosis in portal traid. Besides, some ultrastructural changes were also found in the hepatocytes during the early stage, but not in later stage of ligation. There were mitochodrial swelling, nuclear margination, dilatation of rough endoplasmic reticulum, fatty droplets increase, even, cytolysis. According to the data reported above, it could be suggested that the survival mechanism of bile duct ligated rats was the dilatation, regeneration and recanalization of extrahepatic bile duct, in which, the bile was re-discharged into intestine via the new tract. |
本系統中英文摘要資訊取自各篇刊載內容。