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頁籤選單縮合
題 名 | Liver Histologic Changes in Bile Ligated Rats=大白鼠膽管結紮後肝臟的形態變化 |
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作 者 | 李正華; | 書刊名 | 醫學研究 |
卷 期 | 4:2 1981.07[民70.07] |
頁 次 | 頁1179-1187 |
關鍵詞 | 大白鼠; 肝臟; 結紮; 膽管; |
語 文 | 英文(English) |
中文摘要 | 利用胆管結紮和部份切除之六十隻大白鼠為實驗組,三十四隻僅做開腹探查手術的大白鼠為對照組以進行觀察不同時期的肝組織形態變化。十八隻胆管結紮後的大白鼠在四週內陸續死於膨脹胆管的破裂或出血。兩隻膽管結紮後的大白鼠有自動重建膽管通道的現象。所有活著的大白鼠中,炎症細胞浸潤於門脈區的現象十分輕微,似可說明在膽管結紮後第二十一天發現有膽管性肝硬化並非由於發炎所造成的。連續不同時期觀察膽管結紮後的肝膽組織,發膽管增生在手術後第三天便越明顯,時間愈久愈厲害。門脈區纖維組織的增生則在一星期後可清楚的看到,肝硬化的產生則三星期之後。在膽管結紮後的各期肝組織中,都可見到不同程度的肝細胞壞死和萎縮,同樣肝細胞的再生亦可見到。對照組的大白鼠,除了在手術後頭幾天有輕微的炎症反應外,都沒有其他特殊的變化。 |
英文摘要 | The common bile ducts of sixty adult male rats were lighted and excised and sham operation of thirty four adult male rats were done as controls. Rapture of the proximal stump and infection led to death of eighteen rats within 4 weeks after operation. Two rats with lighted bile ducts undergone spontaneous reconstruction. Inflammatory cells reaction in the portal tracts in all survivals is mild at the first few days and is negligible later, which could not be a direct carouse that induced the proliferation of fibroblastic tissue in the portal tracts. Chronologic sequence of histological changes in liver was recorded thus proliferation of interlobular bile ducts and ductless began at the third day after operation and became worse later, and growth of fibroblastic connective tissue became obvious at not week after operation and cirrhotic change was observed at 3 weeks after operation. Various degrees of hepatocytic necrosis and degeneration went through this study. All of the control group revealed normal liver histology except mild inflammatory cells reaction in the portal tracts at the first few days. |
本系統中英文摘要資訊取自各篇刊載內容。