查詢結果分析
來源資料
相關文獻
- Urine Autoantibodies in Interstitial Cystitis: A Preliminary Report
- Symptomatic Characteristics and Impact on Quality of Life in Patients with Interstitial Cystitis
- 自體抗體與自體免疫疾病
- Bullous Pemphigoid--Analysis of Immunofluorescence Study in 20 Cases
- 令內外科醫生都困惱的疾病--間質性膀胱炎
- Correlation between Clinical Activity Score and Thyroid Autoantibodies in Patients with Thyroid Ophthalmopathy
- 以水疱液做為類天疱瘡之診斷:三病例之經驗
- 間質性膀胱炎的診斷及治療
- Diagnosis of Pemphigus Vulgaris by Immunoblotting of Cultured Human Keratinocyte Cell Extracts
- Urodynamic Results of Intravesical Heparin Therapy for Women with Frequency Urgency Syndrome and Interstitial Cystitis
頁籤選單縮合
| 題 名 | Urine Autoantibodies in Interstitial Cystitis: A Preliminary Report=自體抗體與間質性膀胱炎:初報 |
|---|---|
| 作 者 | 蔡維明; 王翠霙; 郭漢崇; | 書刊名 | 慈濟醫學 |
| 卷 期 | 6:4 1994.12[民83.12] |
| 頁 次 | 頁233-238 |
| 分類號 | 415.835 |
| 關鍵詞 | 自體抗體; 間質性膀胱炎; 免疫螢光; 免疫點漬; Autoantibodies; Interstitial cystitis; Immunofluorescence; Immunoblot; |
| 語 文 | 英文(English) |
| 中文摘要 | 間質性膀恍炎臨床特徵為急尿,頻尿,漲尿時下腹疼痛及解尿後舒服的 現象。受此病影響之膀恍缺乏glycosaminoglycan層,mastcells數目增加及內皮細胞 損傷且有免疫沉積。雖然間質性膀恍炎成因至今未明,此病之特徵包括反覆性發 炎,.單核細胞浸潤及抗核抗體的存在,都顯示出其可能為一種對膀恍產生特異 自體免疫反應的疾病。在此研究中,我們試著釐清此類病人之局部膀胱自體免疫 反應。在12個典型間質性膀胱炎病人尿液中,利用免疫螢光及免疫點漬可以檢測 到自體抗體。這些尿中的自體抗體和血清自體抗體無關,而且血清自體抗體之目 標抗原和尿中自體抗體之目標抗原也不相同。繼續研究這些膀胱特異自體抗體, 可能可以提供一條了解間質性膀胱炎致病機轉的研究途徑。(慈濟醫學 1994;6:233-238) |
| 英文摘要 | Interstitial cystitis is characterized clinically by urgency, frequent urination and suprapubicpain relieved by voiding. Bladders affected by interstitial cystitis have been reported to havedefective glycosaminoglycan layer, increased numbers of mast cells, and injured endothelial cells-with immune deposits. Although the cause of interstitial cystitis is currently unknown, characteristics of the disease including the episodic and remissive chronic inflammation, infiltration withinflammatory mononuclear cells and the presence of antinuclear antibodies implicate that it maybe a bladder specific autoimmune disease or a chronic inflammatory condition of bladder involving an autoimmune response. In this study, we tried to delineate the local bladder autoimmuneresponse in patients with interstitial cystitis. Of the 12 patients who were diagnosed interstitialcystitis by the classic cystoscopic findings after hydrodistension of bladder at a pressure of 70cmH�烙, six patients had detectable autoantibodies in their urine samples either by indirect immunofluorescence or by immunoblotting. The presence of urire autoantibodies did not correlateto the presence of autoantibodies in the sera. Moreover, the potential target autoantigens for seraor urine antibodies are probably different from each other. Further investigation of these bladder specific autoantibodies may provide a route to unravel the pathogenesis of interstitial cystitis.(Tw-Chi Med J 1994; 6: 233-238) |
本系統中英文摘要資訊取自各篇刊載內容。