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題名 | 雨傘節蛇(Bungarus multicinctus)蛇毒對大白鼠離體心房肌細胞的影響= |
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作者 | 李明忠; 吳京一; |
期刊 | 師大生物學報 |
出版日期 | 19940600 |
卷期 | 29:1 1994.06[民83.06] |
頁次 | 頁27-34 |
分類號 | 418.8 |
語文 | chi |
關鍵詞 | 雨傘節蛇毒; 心肌細胞; 活動電位; Bungarotoxin; Cardiac cells; Action potential; |
中文摘要 | 本實驗之目的主要研究雨傘節蛇(Bungarus multicinctus)蛇毒對大白鼠單一心房肌細胞興奮性的影響。以0.1mg/ml蛇毒處理離體心房肌細胞時,其活動電位振幅(amplitude of action potential, APA)及心肌收縮運動速率(HR)並無明顯的改變,但活動電位持續時間(duration of action potential, APD)、PD50、PD75、PD90及心縮機械張力(mechanical tension, MT)等皆有顯著的增加(P<0.05)。若改用0.2mg/ml蛇毒處理離體心房肌細胞時,上述各項因子的變化情形雖大致類似,惟MT在30分鐘後反而逐漸下降。 |
英文摘要 | Bungarotoxin was injected to study effects on cardiac cells of isolated atrium in rats. The results showed that there were no significant changes in amplitude of action potential (APA) and heart rate (RR), but duration of action potential (APD), 50%, 75%, 90% duration of action potential (PD50、PD75、PD90) and mechanical tension (MT) were increased significantly (p<0.05) following administration of bungarotoxin (0.1mg/ml).These factors were also increased following administration of bungarotoxin (0.2mg/ml) except MT. The MT was decreased after 30 minutes following treatment with venom. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。