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題 名 | 子宮內膜異位症患者腹膜滲出液的胚胎毒性因子 |
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作 者 | 王怡芬; 林楠傑; 曾啟瑞; 簡立維; 張淑如; 陳庵君; 吳振森; 鄭慧文; 陳朝洋; | 書刊名 | 北醫學報 |
卷 期 | 23:1 1994.06[民83.06] |
頁 次 | 頁1-9 |
分類號 | 417.27 |
關鍵詞 | 子宮內膜異位症; 腹膜滲出液; 胚胎毒性; Endometriosis; Peritoneal fluid; Embryo toxicity; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究的目的是評估子宮內膜異位症(endometriosis)患者之腹膜滲出腋(peritoneal fluid)對體外培養之兩細胞期小白鼠胚胎發育的影響,並比較此腹膜滲出液中不同成分的胚胎毒性。以子宮內膜異位症患者之腹膜滲出液加入兩細胞期小白鼠胚胎的體外培養系統中,72小時後,與對照組比較發育達囊胚期(blastocyst)的胚胎數目。 進一步再利用超過濾法(ultrafiltration)分離此腹膜滲出液的成分,我們根據分子量及濃度分成四個實驗組:分子量大於 50 kd(A組:10%;B組:20%) 及分子量小於50 kd(C組:10%;D組:20%)。每實驗組的兩細胞期胚胎發育情形皆與對照組作比較。結果在加有子宮內膜異位症患者之腹膜滲出液的培養液中,長成囊胚的胚胎比例(72%)和對照組(88%)比較,呈現顯著的降低(p < 0.01)。經超過濾分離之後,D組(分子量小於50 kd,濃度20%)長成囊胚的胚胎比例(74%)亦呈現顯著的下降(p < 0.01)。 |
英文摘要 | The objectives of this research are to evaluate the effect of peritoneal fluid (PF) from patients with endometriosis on in vitro development of 2-cell mouse embryos and to compare the embryo toxicity between different contents of PF. Mouse 2-cell stage embryos were collected and cultured with PF of endometriosis. The number of embryos reaching blastocyst stage was compared with the control. The contents of PF of endometriosis were further ultrafiltrated and divided into 4 groups according to the molecular weight (MW) and con-centration: MW > 50 kd (group A: 10%; group B: 20%) and MW < 50 kd (group C: 10%; group D: 20%).The development of 2-cell embryos in each group was compared with the control. The percentage of blastocyst formation was significant lower in PF of endometriosis (72%) compared with the control (88%. p < 0.01). After ultrafiltration, there was a significant decrease in blastocyst formation in group D (74%, p < 0.01). After ultrafiltration of the PF of endometriosis, components whose MW smaller than 50 kd at con-centration of 20% have significant toxicity on mouse 2-cell embryos reaching blastocyst stage. |
本系統中英文摘要資訊取自各篇刊載內容。