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題名 | 鯨蠟醇對ketoprofen經皮吸收的影響 |
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作者姓名(中文) | 林恆弘; 許立人; 孫明輝; 蔡義弘; | 書刊名 | 嘉南學報 |
卷期 | 19 1993.11[民82.11] |
頁次 | 頁14-20 |
分類號 | 418.11 |
關鍵詞 | 鯨蠟醇; 脂肪醇與丙二醇混合基劑; 經皮吸收; 體外實驗; 體內實驗; 生體可用率; Cetyl alcohol; FAPG base; Percutaneous absorption; In vitro; In vivo; Bioaviability; |
語文 | 中文(Chinese) |
中文摘要 | 本研究主題是探討在脂肪醇與丙二醇混合基劑軟膏中,添加鯨蠟醇對主 成分藥物經皮吸收的影響。體外實驗是採用C-100繼維素半透膜及兔子的全皮進 行ketoprofen釋出與對皮膚之穿透試驗,並選用兔子從事體內實驗。結果指出, ketoprcfen的藥物釋出動力學可以Higuchi的溶液型模式來解析。硬脂醇以鯨蠟醇部 份取代,對藥物釋出速率的影響並不顯著;再則,ketoprofen之兔皮穿透速率以及 血中濃度是隨著處方中,鯨蠟醇含量增加而下降。綜合言之,體外與體內實驗二 者間存在著良好的相關性;本研究之體外透皮實驗結果可作為脂肪醇與丙二醇混 合基劑軟膏經皮吸收處方預先篩選的依據。 |
英文摘要 | The objective of present study is to investigate the effect of cetyl alcohol which was presentin FAPG bases on the transdennal absorption of ketoprofen. The release and percutaneous penetration kinetics of the drug from FAPG ointments were evaluated in vitro, using C-100 cellulose membrance and full-thickness rabbit skin. In vivo experiments were also examined in rabbits. The results confirm that the release of ketoprofen was interpreted by the Higuchi model ofsolution type. No sgnificant alteration of release rate was observed in partial substituting stearylalcohol with cetyl alcohol. In addition, the penetration rate and the rabbit serum concentration ofketoprofen decreased proportionally when increasing amounts of cetyl alcohol were present in theformulation. It is concluded that good correlation was found between in vitro and in vivo experiments. In vitro experiments are particularly helpful in the studies of ketoprofen in vivo and thebioavailability analysis of the resultant data. |
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