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來源資料
相關文獻
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頁籤選單縮合
| 題 名 | DNA Flow Cytometry in Patients with Operable Gastric Cancer=能手術胃癌病人的去氧核醣核酸(DNA)流動細胞儀檢查 |
|---|---|
| 作 者 | 李威傑; 蒲永孝; 黃夢蘭; 林文傑; 陳楷模; | 書刊名 | 慈濟醫學 |
| 卷 期 | 5:4 1993.12[民82.12] |
| 頁 次 | 頁239-244 |
| 分類號 | 416.243 |
| 關鍵詞 | 胃癌; 流動細胞儀; Gastric cancer; Flow cytometry; |
| 語 文 | 英文(English) |
| 中文摘要 | 對於胃癌組織的DNA含量與各種臨床病理因子間的關係,以及是否影響 預後仍有爭議。本研究乃以流動細胞儀分析64例能手術切除胃癌病人的DNA含 量,同時並分析其與部位、組織學、年齡、性別、期別及無疾病生存期之相關。 整體DNA-非雙套體的比例為34。分化良好的胃癌病例中47.8為DNA-非雙套體, 而分化不良之胃癌組織則為26.8。DNA-非雙套體與腫瘤侵犯的深度呈現有意義的 相關(p<0.05)。對於可手術切除之進行性胃癌病例,無疾病的一年存活率為75.8, 其中非雙套體腫瘤為71.4,而雙套體腫瘤為89.5,但是彼此間並未呈現統計學上 之意義。這些結果顯示DNA套數和腫瘤的侵犯有相當密切的關係。在可切除的進 行性胃癌,DNA-非雙套體似乎較DNA-雙套體有較差的預後,特別是在分化較佳 的(腸型)胃癌病人。關於DNA含量在胃癌病人的意義,仍需進一步的研究及追 蹤。(慈濟醫學1993;5:239-244) |
| 英文摘要 | The relation between DNA content and clinicopathologic parameters as well as the influenceon the prognosis in gastric cancer is controversial. Flow cytometric studies were performed prospectively in 64 patients with operable gastric cancer and analyzed for association with site, histology, age, sex, stage and disease free survival. The total rate of DNA-aneuploidy was 34. DNAaneuploidy was found in 47.8 of well or moderately differentiated carcinoma and in 26.8 ofpoorly differentiated carcinoma. DNA aneuploidy significantly correlated with the depth of tumorinvasion (p<0.05). The one-year disease-free survival rate for patients with resectable advancedgastric cancer was 75.8, and was 71.4 for aneuploid tumor and 89.5 for diploid tumorrespectively. However, this was not statistically significant. These results indicate a close correlation between DNA ploidy and tumor invasion. DNA-aneuploid tumors seem to be associated witha worse prognosis when compared to DNA-diploid tumors in resectable advanced gastric cancer,especially in intestinal type gastric cancer. Further analysis and follow up is indicated to studythe clinical implication of DNA ploidy in gastric cancer patients. (Tzu-Chi Med J 1993; 5: 239-244) |
本系統中英文摘要資訊取自各篇刊載內容。