查詢結果分析
相關文獻
- Pharmacoscintigraphy: Techniques for Studying Durg Release And Absorption in Human
- 經皮給藥新劑型--控制釋放技術在醫藥上的新應用
- 生物吸收性高分子植入物之組織工程與藥物釋放應用
- 經皮吸收藥物控制釋放設計與驗證模式最新發展
- 選擇性血清素再吸收抑制劑
- Pharmacokinetics of Sustain-Released Theophylline in Asthmatic Patients With Nocturnal Dyspnea
- 標識式給藥劑型之設計
- Bupropion--作為戒菸療法之用
- Antagonizing Effects of Type I Antifreeze Protein on Ca叐 Uptake in Fish To-2 Cells
- SAR量測技術
頁籤選單縮合
題名 | Pharmacoscintigraphy: Techniques for Studying Durg Release And Absorption in Human=Pharmacoscintigraphy:研究藥物在人體的釋放與吸收之 技術 |
---|---|
作者 | 陳桂恆; |
期刊 | 藥物食品分析 |
出版日期 | 19930900 |
卷期 | 1:3 1993.09[民82.09] |
頁次 | 頁235-244 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | 人體; 吸收; 藥物; 釋放; |
英文摘要 | In vivo drug release and absorption in the gastrointestinal tract are governed by a complex process subject to many variables. Extensive efforts were spent in studying the durg and manipulating the excipient and mechanical design of the formulation but little is known regarding the physiological factors that influence the release and absorptive processes. Understanding of the behavior of formulation inside the GI tract has been made by gamma scintigraphy using a single isotope. However, the technique is suffering from several limitations : (1) anatomical location of the object is difficult to determine; (2) quantification of radioactivity is difficult due to tissue attenuation and movement of isotope; (3) cannot distinguish between a radionuclide present as a solid or as a solute; (4) preparation of the radiolabeled dosage forms are problematic; and (5) neither the drug nor the excipients can be labeled with nuclide. These problems can be partly alleviated by using dual isotopic, geometric mean measurement, perturbed angular correlation, neutron activation, and pharmacokinetic techniques. Combining several scintigraphic techniques with pharmacokinetics can drastically improve the quality of the data. Thus, the term pharmacoscintigraphy was coined. The application of pharmacoscintigraphy can be further supplemented by other techniques such as stable isotope with gas chromatography-mass spectrometry, pH monitoring and gastrointestinal intubation. Those techniques can be used either independently or simultaneously with pharmacoscintigraphy to provide us with a full picture of durg release and absorption in humans. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。