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題名 | Determination of Ondansetron and Metabolites in Plasma and its Pharmacokinetics in Cancer Patients=Ondansetron 及其代謝物之血漿濃度測定及其在多劑量藥動學之應用 |
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作者 | 胡幼圃; | 書刊名 | 藥物食品分析 |
卷期 | 1:1 1993.01[民82.01] |
頁次 | 頁35-42 |
分類號 | 418.6 |
關鍵詞 | 代謝物; 血漿; 測定; 劑量; 濃度; 藥動學; Ondansetron; Assay method; Pharmacokinetics; Cancer patients; |
語文 | 英文(English) |
英文摘要 | Ondansetron is a novel 5-hydroxy-tryptamine3 (5-HT3) receptor antagonist which is a drug used clinically for chemotherapy-, radiotherapy-and postoperation induced nausea and emesis. A simple, sensitive, precise and accurate HPLC method for the determination of ondansetron and its metabolites 7-hydroxy-ondansetron and 8-hydroxy-ondansetron in plasma is reported. Samples were prepared by a traditional, inexpensive solvent extraction method,The method employed a CN analytical column with an isocratic mobile phase of 20% acetonitrile in 80% 0.0125 M NH4OAc (pH=4.7)and ultraviolet detection at 305nm. Using this method, the calibration curves of ondansetron, 7-hydroxy-ondansetron and 8-hydroxy-ondansetron in plasma in the range of interest (20-800 ng/m1, 100-800 ng/ml and 100-1000ng/ml , respectively) showed good linearity (r>0.999) and precision(both between-day and within-day coefficients of variation less or around 10%).The lower detection limits of this assay method for ondansetron and its 7-OH and 8-OH metabolites were 5 ng/ml, 10ng/ml and 10 ng/ml respectively.This method has been successfully applied to the pharmacokinetic study of ondansetron in cancer patients receiving single i.v. infusion followed by a multiple oral dose of ondansetron. |
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