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題名 | Application of Autologous Fibrin Glue in Assisted Wound Closure--Clinical and Animal Studies=自體纖維蛋白膠對傷口縫合之動物實驗及臨床使用 |
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作者 | 林煌基; 王先震; 陳天牧; 趙壯飛; |
期刊 | 中華民國外科醫學會雜誌 |
出版日期 | 19950700、19950800 |
卷期 | 28:4 民84.07-08 |
頁次 | 頁268-273 |
分類號 | 416.41 |
語文 | eng |
關鍵詞 | 自體纖維蛋白膠; 傷口縫合; 動物實驗; Autologous; Fibrinogen; Fibrin glue; |
中文摘要 | 本實驗的目的是利用動物及臨床病例兩種模式,觀察自體纖維蛋白組織膠,對組織黏連癒合能力的效應。 從血漿中萃取纖維蛋白原,混合牛血漿提煉之凝血酵素,可製成穩定的纖維蛋白組織膠。將大白鼠股動、靜脈切斷後,先予血管顯微縫合,再輔以纖維蛋白組織膠黏連之動物實驗,觀察其癒合過程及組織切片。結果顯示,手術中出血少,術後癒合正常,血管中無血栓形成,通暢良好。在52例不同類別的整形重建手術中,曾使用患者自體組織膠輔助治療。經至少一年以上的追蹤,評估組織膠黏合能力。結果顯示,組織膠對下述狀況有益:(1)清創術後無法結紮或電燒止血的嚴重滲血;(2)植皮術時臉頸等困難皮膚固定區域的固定;(3)減少血管顯微吻合後漏血,避免不必要修補,亦有助血管通暢。在所做重建手術中,均能成功輔助治療,無失敗案例。自體纖維蛋白組織膠又可減少肝炎、AIDS等病毒感染。因此它是方便有效的無線縫合材料。 |
英文摘要 | For evaluating the potential improvement in clinical suture processes by use of "autologousfibrin glue", clinical patient observations and animal studies were designed. The "fibringlue" was initiated by mixing the fibrinogen and factor XIII extracted from host plasma under aseptic conditions. Immediately before application of fibrin glue to the suture region, the extracted bovine thrombin with calcium was then thoroughly mixed with the previously initiated mixture. In animal studies, rat femoral arteries and veins were artificially transected, followed by anastomoses with additional fibrin glue applied to the suture region. Two weeks later, the gross and histological structures of the anastomosed vessels were observed. It was found that the anastomosed site of the vessels were patent without plaque formation in the lumen. In clinical trial, fifty-two cases in different suture conditions were selected and treated with autologous fibrin glue to evaluate their sealing ability. The results indicated that autologous fibrin glue was beneficial in: 1) assisting cessation of severe oozing over the debrided area which had been managed with difficulty by electrocauterization or ligation; 2) promoting adherence of grafted skin, especially over hard immobilized areas such as the face, neck, scapular region and intricate surface; 3) increasing the sealing, and halting vascular leakage to assist the anastomosis; and 4)eliminating disease transmission. Therefore, autologous fibrin glue is a valuable assisted biological suture material. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。