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題 名 | 以豬與犬肋骨製成之去礦物質骨粉移植於犬頭骨缺損之研究 |
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作 者 | 洪瑞鴻; 林安仲; 徐興鎔; | 書刊名 | 國立臺灣大學農學院研究報告 |
卷 期 | 31:4 1991.12[民80.12] |
頁 次 | 頁56-74 |
分類號 | 437.66 |
關鍵詞 | 犬; 肋骨; 缺損; 骨粉; 移植; 豬; 頭骨; 礦物質; |
語 文 | 中文(Chinese) |
中文摘要 | 為探討以豬與犬肋骨製成之去礦物質骨粉對犬骨頭缺損之誘發甘之生 成(Osteogenesis)與移植部位組織之變化,將健康成犬12頭分成二組寅驗。第一組 10頭移植豬去礦物質骨粉(Demineralized bone powder);第二組 2頭則移植犬去礦物 質骨粉。移植前,在犬頭骨左右兩側各取下一直徑2cm之頭骨後,一側移植直徑 50至800μm大小之豬或犬之去礦物質骨粉,另一例則為不處理對照。第一組於移 植豬去礦物質骨粉後,2、3、4、5、6、7、8、9、12及16週,第二組則於移植犬 去礦物質骨粉之犬隻則於術後4及12週,分別隨機選取一頭犬隻行病理學檢查, 以瞭解移植部位與鄰近組織之病變。於第一組經豬去礦物質骨粉移植後2週,在 移植部位之骨粉中有間質細胞侵潤;6週時可見骨母細胞 (Osteoblast)排列於骨粉 表面,9週時有骨細胞(Osteocyte)生成;12週時除有骨細胞生成之外,並有軟骨細胞 生成:16週時已有成熟骨與哈弗氏系統之骨板形成。第二組移植犬去礦物質骨粉 12週時,在移植部位亦發現有骨細胞生成。所有對照組未移植骨粉之頭骨缺損, 皆無新骨生成。由本實驗得知,豬與犬之去礦物質骨粉移植於犬之頭骨缺損,對 該部位均有誘發生骨之作用。由於豬去礦物質骨粉易於收集、製備及滅菌保存等 優點,故此種骨粉似可應用於犬之骨移植。 |
英文摘要 | Osteogenesis and histopathological changes of the skull defectfollowing implantation with porcine and canine demineralized rib bonepowder were studied in 12 adult dogs. The experimental animals weredivided into 2 groups: group 1, ten dogs implanted with porcinedemineralized bone powder in the left side of skull defect subsequentlyto the removal of skull bone pieces; Group 2, 2 dogs implanted withcanine demineralized bone powder in the left side of skull defectsubsequently to the removal of skull bone pieces. In group 1, each of the 10 dogs were killed at 2,3,4,5,6,7,8,9,12 and16 weeks post implantation (PT), respectively, for pathologicalexamination; while the 2 dogs in group 2 were killed at 4 and 12weeks PT, respectively, for pathological examination. In group 1, marked infiltration of the mesenchymal cells in thebone powder and numerous osteoblasts lining the borders of the bonepowder in the transplantation site were noticed after 2 and 6 weeksPT, respectively. In addition, osteocytic formation, chondrocyticformation and Haversian system formation were observed after 9, 12and 16 weeks PT, respectively. In group 2, the progressivedevelopment of bone tissue in the transplantation site was muchsimillar to those described in the porcine bone powder. However, nonew bone was observed in the skull defect sites of the controls. The results indicate that both porcine and canine demineralizedbone powder when implanted into the skull defects can stimulateosteogenesis. We concluded that both porcine and canine demineralized bone powder may be used as an inductive agents for osteogenesis, however, the porcine bone powder is more suitable for clinical use in the canine bone transplantation as compared with the canine bone powder since the former is always easy to be collected, prepared and disinfected. |
本系統中英文摘要資訊取自各篇刊載內容。