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題 名 | Stabilities of 阷TcO-CB-PAO Diastereoisomers in Dilute Aqueous Solutions=鎝氧環丁基丙烯氨圬非鏡像立體異構物在水溶液中之穩定性研究 |
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作 者 | 蔡長書; | 書刊名 | 慈濟技術學院學報 |
卷 期 | 5 2003.09[民92.09] |
頁 次 | 頁95-105 |
分類號 | 418.346 |
關鍵詞 | 穩定性; 分解速率; 動力學研究; 放射化學純度; 鎝氧環丁基丙烯氨圬非鏡像立體異構物; 阷TcO-CB-PAO diastereoisomers; Stability; Rate of decomposition; Kinetic study; Radiochemical purity; |
語 文 | 英文(English) |
中文摘要 | 本文主要探討鎝氧環丁基丙烯氨圬(TcO-CB-PAO)非鏡像立體異構物在水溶液中之穩定性。首先合成大量環丁基丙烯氨圬配位子及其鎝錯合物。並在25 ±0.1 ℃與不同的酸鹼條件水溶液下,測定鎝錯合物之分解速率。實驗採用動力學的方法,配製pH值介於4至10,濃度約為5×10 –7 M之稀釋水溶液,並利用溶劑萃取法分離水相及有機相,由其分解速率常數數據來判斷99+99mTcO-CB-PAO非鏡像立體異構物體外穩定特性。鎝錯合物之濃度控制在5×10 –7 M左右,主要為模擬臨床核醫藥物配劑情形,且其活度約為10 mCi至20 mCi使不造成鎝錯合物本身之自分解。根據本文所得結果,99+99mTcO-d,l-CB-PAO在pH值分別為4,5,6,8,10時,其分解速率常數(Kd) 分別為11.0, 7.1, 0.17, 0.14及0.085 hr-1,而99+99mTcO-meso-CB-PAO在pH值分別為4, 5, 6 ,8, 10時,其分解速率常數 (Kd) 分別為4.9, 0.9, 0.028, 0.0072及0.035 hr-1,兩者在鹼性溶液中分解速率常數 (Kd) 變化很小,可評估為鎝錯合物在此條件下較為穩定。由實驗結果得知,99+99mTcO-d,l-CB-PAO不論在何pH值條件下,其分解速率常數(Kd)都比99+99mTcO-meso-CB-PAO大。在6小時內,鎝物種濃度其放射化學純度會隨時間的變化而減小並遵循一級反應。但在酸性條件下兩個鎝錯合物酸分解速率皆比鹼性條件下分解速率快且明顯。 |
英文摘要 | In an attempt to get a better understanding about the in vitro stability of 99TcO-CB-PAO diastereoisomers in dilute aqueous solution, CB-PAO isomers and 99TcO-CB-PAO diastereoisomers were prepared, and the rate of decomposition of the TcO-CB-PAO diastereoisomers were measured under various pH values at 25±0.1 ℃ . In order to simulate the clinical situations, all solutions of 99+99mTcO-CB-PAO diastereoisomers were diluted to ca. 5×10 –7 M. The radioactivity of 99mTc is between 10 to 20 mCi. Kinetic studies were used to evalute the decomposition in the 5 ×10 –7 M aqueous solution of 99+99mTcO-d,l-CB-PAO and 99+99mTcO-meso-CB-PAO at various pH values (4 –10) by solvent extraction method. The rate constant (Kd) at various pH value , e.g. 4, 5, 6, 8, and 10, were found to be 11.0, 7.1, 0.17, 0.14 and 0.085 hr-1, for 99+99mTcO-d,l-CB-PAO, and those for 99+99mTcO-meso-CB-PAO were 4.9, 0.9, 0.028, 0.0072,and 0.035 hr-1, respectively. It is clearly shown that the Kd values of 99+99mTcO-d,l-CB-PAO are larger than those of 99+99mTcO-meso-CB-PAO at pH = 4~10. However, the changing of Kd was not significant when the aqueous solution was adjusted at more basic concentration. The radiochemical purity (%) of TcO-CB-PAO diastereoisomers changed with time elapse under various pH values was also compared duration 6 hours. Kinetic studies on the acid decomposition conditions showed that the first order reaction was obeyed for the decomposition rate of both 99TcO-CB-PAO diastereoisomers. In conclusion, TcO-meso-CB-PAO in a diluate aqueous solution is more stable than that of TcO-d,l-CB-PAO at various pH values tested. It seems that TcO-CB-PAO diastereoisomers are easier to decompose when they were treated by acidic conditions ( pH < 8 ). TcO-CB-PAO diastereoisomers are more stable when they were treated by basic conditions ( pH 8-10). |
本系統中英文摘要資訊取自各篇刊載內容。