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題 名 | Clinical Trial of Corticosteroid and Beta-2 Bronchodilator in Acute Wheezing Infants=試用皮質類固醇及貝他二型支氣管擴張劑治療嬰幼兒喘鳴 |
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作 者 | 林應然; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 32:6 民80.11-12 |
頁 次 | 頁333-340 |
分類號 | 418.263 |
關鍵詞 | 二型; 支氣管擴張劑; 幼兒; 皮質; 貝他; 治療; 喘鳴; 試用; 嬰; 類固醇; |
語 文 | 英文(English) |
中文摘要 | 為瞭解皮質類固醇及貝他二型支氣管擴張劑對嬰幼兒喘鳴病人之臨床療效,台北市立忠孝醫院小兒科於1988年11月至1990年3月間,針對80位年齡小於36個月,因急性喘鳴而住院的病例,嚐試以hydrocortisone及procaterol進行臨床研究,我們將病人分為三組,A組有29人,為年齡小於12個月之治療組;B組有23人,為年齡等於或大於12個月之治療組;C組有28人,為年齡小於12個月之對照組。結果顯示B組之臨床嚴重程度在住院後第四及第五天比A組明顯降低(P值皆小於0.05);在住院後第三、四、五天比C組明顯降低(P值分別小於0.05、0.005及0.05)。B組病人之過去喘鳴次數比A及C組明顯較多(P值小於住0.05),顯示喘嗚症狀在某些病童有再發傾向,對hydrocortisone及procaterol之治療在24小時內有快速良好療效者,三分之二屬於B組,但此種快速良好反應之發生與否無法以病人之個人過去過敏病史,家族過敏病史,血清IgE濃度及全嗜酸性白血球總數預測。 |
英文摘要 | To evaluate the effect of a combination of corticosteroid and beta-2 bronchodilator on acute, young, wheezing patients, a total of 80 patients, ages below 36 months who were hospitalized for this condition during the period November 1988 to March 1990 were studied. They were divided into three groups. Group A consisted of 29 cases, under 12 months old, and treated with hydrocortisone and procaterol, Group B included 23 cases, between 12 and 36 months old, treated as in Group A; Group C, of 28 cases younger than 12 months, received neither drug. The clinical severity scores for Group B were significantly more improved than Group A on days 4 and 5 (p<0.05 and p<0.05, respectively), and better than that of Group Con days 3, 4, and 5 (p<0.05, 0,005, and 0.05, respectively). No significant difference was found between Group A and C from days 1 to 5. The previous wheezy coughing episodes were significantly more frequent in Group B than in Groups A and C (p<0.05). Two-thirds of the quick responders to hydrocortisone and procaterol were 12 months old or older. The personal and family allergic history, serum IgE level, and total eosinophil count could not be used as parameter to predict responsiveness to the combined therapy of hydrocortisone and procaterol. |
本系統中英文摘要資訊取自各篇刊載內容。