頁籤選單縮合
題 名 | Effects of Nebulized Terbutaline on Oxygen Saturation in Acute Asthmatic Children=噴霧性貝他二型支氣管擴張劑對急性氣喘病童血氧飽合濃度之影響 |
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作 者 | 林應然; 謝貴雄; 施宗義; 陳偉德; 吳康文; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 35:5 民83.09-10 |
頁 次 | 頁377-384 |
分類號 | 418.263 |
關鍵詞 | 噴霧性貝他二型支氣管擴張劑; 血氧飽含濃度; 急性氣喘病童; Nebulized beta-2 agonist; Oxygen saturation; Acute asthmatic children; |
語 文 | 英文(English) |
中文摘要 | 為瞭解噴霧性貝他二型支氣管擴張劑對急性氣喘病童血氧飽合濃度之影響。臺北市立忠孝醫院小兒科針對47位年齡介於1.8至14歲的急性氣喘病患進行研究。病童先接受20毫升生理食鹽水超音波噴霧治瞭10分鍾後,再接續使用terbutaline sulphate溶液4毫升(含10毫克)混於20毫升生理食鹽水中做相同治療10分鍾,治療期間皆不使用氧氣。治療前及治療期間以pulse oximeter每隔2分鍾追蹤病童之血氧飽合濃度及脈搏速率,並於治療前,生理食鹽水超音波噴霧治療10分鍾後,和使用terbutaline sulphate溶液治療10分鍾後三階段,評估測試病童之臨床嚴重度分數及最大呼氣流速。研究結果顯示,整體而言病童之血氧飽售濃度在接受生理鹽水超音波噴霧治療10分鍾後,和使用terbutaline sulphate溶液治療(P值分別小於0.05及0.0001)。22位(44%)病童在生理食鹽水超音波噴霧治療10分鍾期間,12位(25%)病童在使用terbutaline sulphate溶液治療10分鍾期間,被發現有血氧飽合濃度降低的現象,但程度皆很輕微,前者平均降低1.62±0.95%(1.00%至4.26%),後者平均降低1.64±0.83%(1.02%至3.13%)。兩者間並無明顯差異。所有7位血氧飽合濃度在研究前等於或低於90%的嚴得氣喘病童,在使用terbutaline sulphate噴霧治療後,其血飽合濃度皆增加而無降低現象發生。病童之臨床嚴重度分數及最大呼氣流速,在使用生理食鹽水超音波噴霧治療10分鍾後,和使用terbutaline sulphate溶液治療10分鍾後,皆比治療前在統計學上有意義增加(p值分別小於0.0001,0.001,當生理食鹽水治療後與治療前做相互比較)。脈搏速率則在整個研究過程中皆無明顯變化。因此我們認為terbutaline sulphate混於生理食鹽水進行超音波噴霧治療對氣喘病童不但有治療效果,並且相當安全,既使不與氧氣合併使用。 |
英文摘要 | To evaluate the paradoxical effect of oxygen desaturation following beta-2 bronchodilator nebulization treatment in acute asthmatic children, a total of 47 patients, aged between 1.8 and 14 years, 27 males and 20 females, were studied. Twenty ml of nebulized normal saline (NS), followed by 10 mg (4 ml) of terbutaline sulphate solution (TSS) in 20 ml NS, were delivered by an ultrasonic nebulizer in 10 min to each patient through a connecting air tube placed in front of the nose and mouth. Oxygen saturation (Sa02) and pulse rate were monitored, using a pulse oximeter, before study and every two minutes until the end of the study. The clinical severity score and peak expiratory flow rate (PEFR) were checked before the study, at the end of inhalation of NS, and at the end of inhalation of TSS. SaO2 was increased both after nebulized NS and TSS when compared with the prestudy data (p<0.05 and p<0.0001, respectively). Twenty two cases (47%) during NS and 12 cases (25%) during TSS nebulization had SaO2 below the pre-study level. The mean decrease of SaO2 for the former was 1.62±0.95% (range: 1.00% to 4.26%), and 1.64±0.83% (range: 1.02% to 3.13%) for the latter (p>0.9). No SaO2 decrease after nebulized TSS was observed in any of the seven severe asthmatic children with a prestudy SaO2 ≤90%. The clinical severity score and PEFR were also significantly improved both after nebulized NS and TSS (p<0.0001 and p<0.001, respectively for NS, and both p<0.0001 for TSS). Furthermore the improvement after TSS was much greater than that of NS (p<0.0001 for both parameters). Pulse rate did not change throughout the entire course of study. It is therefore concluded that nebulization of TSS with NS is effective and safe in the treatment of asthmatic children, even without O2 supply. |
本系統中英文摘要資訊取自各篇刊載內容。