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頁籤選單縮合
題 名 | 血管張力素對腎絲球內血流動力和腎小管的作用 |
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作 者 | 黃萬出; | 書刊名 | 醫學研究 |
卷 期 | 11:6 1991.05[民80.05] |
頁 次 | 頁401-407 |
分類號 | 398.3 |
關鍵詞 | 血管張力素; 血流動力; 腎小管; 腎絲球; |
語 文 | 中文(Chinese) |
中文摘要 | 血管張力素在腎血流動力和腎小管功能的調節上扮演著極重要的角色。由靜脈灌注乙型血管張力素會引起與劑量相關的腎血液流量、腎小球濾過率和過濾係數之下降及過濾分率的增高。而腎內生成的乙型血管張力素對腎絲球的超過率作用也有著重要的影響。相反地,以藥物阻遏乙型血管張力素會增加腎血液流量和視血壓變化而定的腎小球濾過率之改變。由管周微血管微量灌注血管張力素也會降低單一腎元的腎小球濾過率和腎絲球壓。以血管張力素轉化酶抑制劑阻斷乙型血管張力素的生成會減弱腎小管--腎絲球迴饋機制,而由靜脈或管周微血管灌注乙型血管張力素會增高此一迴饋的反應性。除外,乙型血管張力素對近側腎小管重吸收鈉視劑量而有促進和抑制的雙向作用,其促進重吸收作用與蛋白質激酶C的被激活及/或腺嘌呤環苷酶的抑制有關,而細胞內游離鈣因乙型血管張力素而增加可能是導致近側腎小管重吸收的抑制有關。 |
英文摘要 | Angiotensin plays an important role in the regulation of renal hemodynamics and tubular function. Systemic infusion of angiotensin II (ANG II) produces dose –dependent decreases in renal blood flow (RBF) and filtration coefficient, and increases in filtration fraction. Intrarenally genearated ANG II is also critical to alterations in glomerular ultrafiltration. Pharmacological blockade of ANG II elicits increases in RBF and pressure associated changes in GFR. Peritubular capillary microperfusion of ANG II results in decreased single nephron GFR and glomerular capillary pressure. Blockade of ANG II activity by ANG coverting enzyme (ACE) inhibitor markedly attenuates whereas intravenous or peritubular capillary infusion of exogenous ANG II enhances tubuloglomerular feedback (TGF). Besides, ANG II exerts a dose –dependent biphasic effect on proximal tubular sodium reabsorption. The stimulatory effect of ANG II on proximal sodium reabsorption is associated with activation of protein kinase C and/or inhibition of adenylate cyclase, whereas cytosolic free calcium surge activated by ANG II may be part of a cellular message that inhibits proximal tubular reabsorption. |
本系統中英文摘要資訊取自各篇刊載內容。