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題名 | 巴拉松對大白鼠運動神經元及運動終板超微結構的改變 |
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作者 | 許文重; 瞿德璐; 劉江川; | 書刊名 | 醫學研究 |
卷期 | 11:2 1990.09[民79.09] |
頁次 | 頁57-70 |
分類號 | 418.8 |
關鍵詞 | 巴拉松; 改變; 神經元; 終板; 超微結構; 運動; 鼠; |
語文 | 中文(Chinese) |
中文摘要 | 巴拉松(Paraxon)為一有機磷化合物(organophosphatic compound),亦是一強而有力的殺蟲劑,同時也為一種不可逆的抗膽素脂?(irreversible anti-cholinesterase),故當巴拉松與聯會(synapses)處的膽素脂?(cholinesterase)結合以後會讓膽素脂?失去活性,這就是巴松致毒的主因。我們使用大白鼠以巴抗松0.5mg/kg/day皮下注射。從注射後30分鐘至21天,然後以電子鏡(electron microscopy)分別觀察大白鼠腰脊髓前角(anterior horn)及橫膈肌的運動終板(motor end plate)其漸進式的變化。在大白鼠腰脊髓前角(anterior horn)及橫膈肌的運動終板(motor end plate)其漸進式的變化。在大白鼠腰脊前角,軸突的髓鞘(myelin shetath)隨著注射次數的增多及時間的增長,其鬆散的程度也更為加重,也就是去髓鞘(demyelination)的作用日益增加。並且在樹突,及軸突內可發現緻密板狀及膜狀三結構,這些結構也是退化的指標。另外對運動神經元(neurons)的胞體可以產生斑馬狀的Zebra body。巴拉松對於聯會下組織當?傷害包括肌纖維的線粒體(mitochondria)產生空白斑痕(clear patch)?(ridge)產生斷夸,而且使肌漿網(sarcoplasmic reticulum)及橫管(T tubule)產生明顯的擴張現象,以及產生膜狀螺環(membranous whorl)。 |
英文摘要 | Paraoxon is one of the organophoshatic compound that is a strong and powerful insecticide. In biochemistry, it is a irreversible antichlinesterase. When paraoxon interacts with cholinesterase at the synapses, cholinesterase will loss its biochemical activity. This is the major process of pathogenesis in paraoxon. Syraque-Dawley rats were given paraoxon by subcutaneous injection at a dosage of 0.5mg mg/Kg/day. Thirty minutes to twenty-one days after injection of paraoxon the anterior horn of lumbar spinal cord and moor end plate of diaphragmatic muscle were observed under electron microscopy. At the anterior horn of lumbar spinal cord, axonal myelin steathes were puffy in appearance. The degree of puffy myelin worsend according to the time of injectionand duration of time involved. We also discovered membranous and lamellar structures in the dendrites and xaons. These sructuers are the indicators of degeneration. The cell bodies of neurons were able to create “Zebra body”. At the motor end plate of diaphragmatic muscle, course granular vesicles to be found over subsynaptic organizations. Paraoxon also damages the subsynaptic organization including (1) clear patch and ridge disrupted at mitochondria (2) obviously dilated over sarcoplasmic reticulum and transverse tubules in muscle fibers (3) generated membranous whorl within the muscle fiber. |
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