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頁籤選單縮合
題名 | 草菇毒蛋白 A[feaf]對大白鼠離體心房之電生理研究 |
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作者姓名(中文) | 童麗珠; 吳京一; | 書刊名 | 師大生物學報 |
卷期 | 23 1988.10[民77.10] |
頁次 | 頁117-128 |
分類號 | 383 |
關鍵詞 | 大白鼠; 心房; 毒蛋白; 草菇; 電生理; 離體; |
語文 | 中文(Chinese) |
中文摘要 | 本實驗主要在研究由草菇(Volvariella volvaceae)抽出的草菇毒素(Volvatoxin A2, VT-A2),對離體大白鼠右心房的電生理作用。利用細胞內記錄法,來記錄心肌活動電位的零期最大上升速率(dV /dt max )、振幅(amplitude of action Potential, AP)、靜止膜電位(resting potential, RP)、over shoot potential(OP),持續時間( duration of action potential, PD)和膜反應性。同時利用肌肉等張收縮記錄法記錄心縮機械張力(MT)。所有數據均用統計分析處理。 結果顯示:以不同濃度(20、10、5μg/ml)VT-A2處理後,分別在7、15、20分鐘內,dV/dt max、AP、RP、OP、和MT (P< 0.01)即有顯著性的下降。處理VT-A25μg/ml後,用Tyrode溶液洗濯,100分鐘後,活動電位的dV / dt max、AP和RP幾乎可恢復至原來值。草菇毒素對PD的變化是沒有統計上的顯著性(P>0.05)。 |
英文摘要 | Effects of Volvatoxin A2 (VT- A2 , extracted from edible mushroom, Volvariella volvaceae) on the isolated rat right atrial myocardium were investigated electro-physiologically. The maximum rate of rising phase 0 ( dV/dt max.) , amplitude (AP), resting potential (RP) , over shoot potential (OP), duration (PD) and membrane responsiveness of the cardiac action potential were studied with intracellular recording method. The systo-lic mechanical tension (MT) of the myocardium was iso-tonically recorded. All data were analyzed with statis-tical means. Result s showed that there were apparent dose and time - dependent decrease in dV/dt max. of phase 0 , AP, RP , OP , membrane responsiveness and MT, but increase in diastolic resting tension. After different concentrat-ions of VT- A2 ( 20, 10, 5μg /ml) were administered to the myocardium, there were significant decreases in dV/dt max, AP, RP, OP and MT( P<0.01) within 7, 15 and 20 minutes respectively. One hundred minutes after removal of the VT-A2 (5μg/ml) treatment, the dV/dt max., AP and RP of cardiac action potential nearly recovered to its original values. The decrease of action potential duration was not significant (P.> 0.05) . |
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