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頁籤選單縮合
題名 | In Vitro Susceptibility of Angiostrongylus cantonensis to Chemotherapeutic Compounds=廣東住血線蟲對化學藥物之體外感受性 |
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作者 | 趙大衛; | 書刊名 | 師大生物學報 |
卷期 | 23 1988.10[民77.10] |
頁次 | 頁85-94 |
分類號 | 418.11 |
關鍵詞 | 化學; 血線蟲; 感受性; 廣東; 藥物; 體外; |
語文 | 英文(English) |
中文摘要 | 本研究由實驗感染的大白鼠收集台灣品系廣東住血線蟲之第五期幼蟲,並測定其在體外對四種常用驅蟲藥物的感受性,幼蟲清洗、分組後在24糟組織培養盤中浸置於Earle培養液內。將atabrine, mebendazole, praziquantel及DEC等四種治療線蟲感染的合成藥物配置成不同濃度測定幼蟲對藥物的感受性,結果顯示在半小時內1mg / ml的atabrine或DEC均可抑制蟲體運動,mebendazole或praziquantel無法達到此效果,四小時後atabrine處理組所有幼蟲完全麻痺,而以mebendazole或praziquantel處理者則可達到半數以上(ID60),其中praziquantel 的效果比mebendazole又略差。本研究所得結果,在治療藥物的篩選工作上極有幫助。 |
英文摘要 | In vitro susceptibility of fifth-stage larvae of Angiostrongylus cantonensis to four different anthelmintic drugs was investigated. Larvae of Taiwan strain of A. cantonensis were collected from experimentally infected rats. They were washed, grouped, and cultivated in the incubation medium in the wells of a 24-well tissue culture plate. Four synthetic compounds commonly used against nematode parasites were compared to determine the suscepti-bility of these larvae to different concentrations of drugs. These are quinacrine dehydrochloride atabrine (atabrine), mebendazole, praziquantel, and diethylcarbamazine (DEC). Atabrine and DEC caused 50% inhibition (ID50) in half an hour at a concentration of 10-8 mg/ml or more. Atabrine paralyzed the parasite completely four hour after incubation. Mebendazole and praziquentel had ID50 in 4 hr at a concentration of 1 mg/ml. Compare to mebendazole, praziquantel showed even less larvicidal effect on A. cantonensis. The results obtained from this in vitro study may help in the preliminary screening for an adequate treatment of clinical cases. |
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