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題 名 | 氣喘病兒嗜中性白血球吞噬功能與血清組織胺之相關關係 |
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作 者 | 劉文章; 江季勛; 黃德揚; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 27:1 民75.01-02 |
頁 次 | 頁26-33 |
分類號 | 417.5343 |
關鍵詞 | 吞噬; 氣喘; 嗜中性白血球; 血清組織胺; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究對36名正值氣喘發作的病兒及52名年齡相近的正常兒童,經雙親同意之下,經由末梢抽血檢查其血清組織胺值,嗜中性白血球吞噬N. B. T.功能,及血清對第三者之嗜中性白球吞噬功能之抑制作用等。其結果發現在其中的27名病兒之血清組織胺值為1.34±0.97 ng/ml,而52名正常兒童的血清組織胺值為0.40±0.38 ng/ml,統計比較兩者雖不呈現有意義的差異(t=1.45, P>0.1),但病人高於1.0 ng/ml之人數較多且分佈較擴散,不若正常兒童之集中。在嗜中性球之吞噬N. B. T.功能檢查上,39名正常兒童之吸光度為0.031±0.016,加入刺激劑後其值為0.061±0.023,在培養液中如加入組織胺使成1 ng/ml, 10 ng/ml及100 ng/ml之濃度時,則其值稍呈下降為0.056±0.0253, 0.057±0.027,而26名病兒之嗜中性球吞噬功能之吸光度為0.032±0.015,加入刺激劑後其值為0.055±0.018,於培養液如組織胺濃度為1 ng/ml, 10ng/ml及100 ng/ml時其吸光度為0.051±0.022, 0.047±0.022及0.044±0.017,兩羣之各值相比較雖亦不呈現有意義之差異但病兒之吸光度很顯然的比正常兒童低。於培養液中如加入組織胺之拮抗劑時其結果發現H2拮抗劑對組織胺有很好的拮抗作用,而可使細胞吞噬功能昇高,而相反的,H1拮抗劑卻使吞噬功能更形低下。從病兒之嗜中性球吞噬N.B.T.之吸光度與其血清組織胺濃度的相關關係上發現其吸光度之下降與組織胺之增加有關,尤其是經刺激劑加入之吸光度,其關係更具意義(r=0.41, t=2.42, P<0.05)。36名病兒血清與19名正常兒童血清對第三者嗜中性球吞噬功能之抑制作用上發現病兒確存在有某種抑制素,而可抑制正常嗜中性球之吞噬功能。 |
英文摘要 | This study was conducted with thirty-six children during asthmatic attacks and with fifty-two normal children who acted as age matched controls. Consent of the children's parents was obtained prior to any experimental procedures. Tests were performed to detect serum histamine concentrations, neutrophil phagocytic function and the presence of serum inhibitor in bloods drawn from each child. The presence of a serum inhibitor was indicated by suppression of the phagocytosis of the donors' neutrophils. The mean concentration of serum histamine in 27 asthmatics was 1.34±0.97 ng/ml, and was 0.40±0.38 ng/ml in 52 normal controls. The difference in concentration levels between these two groups was not biostatistically significant (t=1.45, P>0.1). However, an extremely wide range of serum histamine concentrations were found in the asthmatic group. Three types of neutrophil phagocytic function tests (N. B. T. test) were performed in 39normal controls and 26 asthmatics. The first type, in normal controls, with pool human serum and N.B.T. reagent had a mean optic density (O.D) variable of only 0.031±0.016. The stimulant was added in the second type of test, and the O.D. elevated to 0.061±0.023. However, in the third type of test, where the medium contained 1ng/ml, 10ng/ml or 100ng/ml of histamine, the O.D. slightly declined to 0.56±0.023, 0.053±0.027 respectively. The O.D. for the asthmatics was 0.032±0.015 in the first type of test, 0.055±0.018 in the second, and 0.051±0.022, 0.47±0.022 and 0.044±0.017 under the 3 conditions of the third type of test. Although the difference in each pair of values between both groups was not biostatistically significant, a lower level of O. D. were nevertheless detected in the asthmatic group. The asthmatic patients were more susceptible of the neutrophil phagocytasis to histamine concentration change than were the normal controls. Although, the rate of decrease of the neutrophil phagocytic function was enhanced by H1-antihistamine, the phagocytic function was increased by H2-antihistamine. There was not a high correlation between O.D. of the neutrophil phagocytic function and serum histamine levels (r=0.346, P>0.05). However, after the stimulant was added, a close correlation was found (r=0.410, P<0.05). The serum from 36 asthmatics revealed a more significant suppression of neutrophil phagocytic function than did the 19 normal controls. These results indicate that the defects in the neutrophil phagocytic function in asthmatics occur both intracellularly and extracellularly. These defects may be either a result of frequent and sustained high serum histaminemia or from an unidentified inhibitor located in the serum. |
本系統中英文摘要資訊取自各篇刊載內容。