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題名 | 年輕婦女接種德國麻疹(RA27/3 Strain) 疫苗後之臨床及血清學反應 |
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作者姓名(中文) | 林定邦; 高全良; 李慶雲; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 26:5 民74.09-10 |
頁次 | 頁426-429 |
分類號 | 414.82 |
關鍵詞 | 反應; 年輕; 血清學; 疫苗; 婦女; 接種; 麻疹; 德國; 臨床; |
語文 | 中文(Chinese) |
中文摘要 | 80位年輕婦女接受德國麻疹RA 27/3 strain 疫苗接種,接種後第10天至20天有24人(30%)出現臨床反應,其發生率依序為-倦怠22.5%、出疹17.5%、淋巴腺腫大17.5%、發燒13.75%、開節症狀11.25%。接種者中有一名護士出現較嚴重之臨床反應,而愈年輕接種者出現臨床症狀機會愈少。第31天後所有接種者皆出現血球凝集抑制及螢光免疫抗體,至目前已維特一年以上。 |
英文摘要 | The rubella vaccine (RA 27/3 strain) was inoculated to 80 young susceptible female adults on voluntary basis. Clinical reactions such as malaise, skin rashes, lymphadenopathy, fever or arthralgia were observed in 24 volunteers (30%). The incidence of individual clinical reaction in the order of frequency was malaise 22.5%, rash 17.5%, lymphadenopathy 17.5%, fever 13.8% and joint symptoms 11.3%. All vaccinees with clinical reactions other than malaise were at the age of 20 years or older. These clinical reactions occurred between 10 and 20 days after vaccination. Only a nurse who had high fever, malaise, skin rashes, arthritis, lymphadenitis and dizziness was severe enough to require a medical treatment. All 80 vaccinees developed both HAI and FIA antibodies against rubella viruses 31 days after vaccination and persisted at a high level for at least one year. It is suggested that RA 27/3 strain of rubella vaccine is safe and very effective if given before adolescence. |
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