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頁籤選單縮合
題名 | Evaluation of a Live Attenuated Varicella Vaccine in 15-to 18-Month-Old Healthy Children=活性減毒水痘疫苗接種於15-18月大健康幼兒之評估 |
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作者姓名(中文) | 盧孟佑; 黃立民; 李慶雲; 李秉穎; 丘秀慧; 蔡秀媛; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 39:1 民87.01-02 |
頁次 | 頁38-42+70 |
分類號 | 414.82 |
關鍵詞 | 活性減毒水痘疫苗; 疫苗接種; 麻疹; 德國麻疹; 腮腺炎; Varicella-zoster virus; Vaccine; Measles; Mumps; Rubella; |
語文 | 英文(English) |
中文摘要 | 為評估活性減毒水痘疫苗對15-18月大健康幼兒之安全性及免疫效益,本研究對 118位15至18月大的健康幼兒,同時分開接種一劑活性減毒水痘疫苗和一劑麻疹-德國麻 疹-腮腺炎混合疫苗於左右大腿,觀察其副作用及免疫效益。結果顯示注射反應極輕微,約 2%接種者出現皮疹,但都沒有水泡出現。接種後六週測血清免疫反應,100%接種者對水痘 病毒產生免疫力。與麻疹-德國麻疹-腮腺炎混合疫苗同時分開接種並未減低麻疹-德國麻 疹-腮腺炎混合疫苗之效益或增加接種反應性。由此研究可發現活性減毒水痘疫苗和麻疹- 德國麻疹-腮腺炎混合疫苗混合同時接種是相當方便、安全且有效的措施。 |
英文摘要 | A clinical trial was conducted in Taiwan in 15- to 18-month-old healthy children to study the reactogenicity and immunogenicity of live varicella vaccine combined with standard measles- mumps-rubella vaccine. A total of 118 varicella antibody-negative children were enrolled. They received one dose of varicella vaccine and one dose of measles-mumps-rubella vaccine at the same time. The vaccines were well tolerated; adverse reactions were mild and infrequent, with 2% of vaccinees developed skin resh. No vesicular rash war seen. Concomitant varicella vaccination did not significantly increase the incidences of reactions associated with MMR vaccine. The seroconversion rates to varicella, measles, mumps and rubella all approached 100%. This study confirmed that simultaneous administration of live attenuated varicella vaccine and MMR vaccine was safe and immunogenic in healthy young children in Taiwan. |
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