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| 題 名 | Test Dipstick for Determination of Urinary Protein, Creatinine and Protein/Creatinine Ratio=新式尿液常規試紙檢測尿蛋白、尿肌酸酐及尿蛋白/肌酸酐比值之可用性與臨床檢驗價值研究 |
|---|---|
| 作 者 | 王俊民; 林啓畬; 蔡奉安; 陳靜宜; 高玉眞; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 21:1 2009.03[民98.03] |
| 頁 次 | 頁23-28 |
| 分類號 | 415.122 |
| 關鍵詞 | 肌酸酐; 尿蛋白/肌酸酐比值; 尿液試紙; Creatinine; Protein/creatinine ratio; Clinitek atlas PRO 12 reagent pak; |
| 語 文 | 英文(English) |
| DOI | 10.30046/JBLS.200905.0004 |
| 中文摘要 | 許多文獻顯示,尿液中少量白蛋白的增加可以用來評估早期腎病變及阻止糖尿病或高血壓的高危險族群進展成末期腎病變。然而因目前使用之常規尿液試紙敏感度限制,特別是當尿蛋白濃度介於+/-(trace)的時候,容易因爲尿液濃度之稀釋或是濃縮的情況而造成錯誤的報告。檢驗室因此需要以其他檢測方式進行確認。本實驗中,我們對門診301位病人之隨機尿液檢體,測試了新的尿液檢驗試紙,新增了白蛋白(albumin)和肌酐酸(creatinine)項目,使原來尿蛋白檢查的檢驗結果加上新的albumin pad得到較精準的protein結果;測試Creatinine的結果則以排除尿液濃度造成的錯誤判斷並提供計算protein/creatinine ratio,藉此可減少尿液檢測僞陽或僞陰性發生,得到較精準之P/C Ratio結果參考。我們比較試紙法所得到的尿蛋白及尿肌酐酸及P/C ratio與定量法之間的相關性,發現兩者間具有很高的相關性,尤其在P/C ratio的項目中,試紙法與定量法比較,具有98%以上的敏感性,相較於傳統僅以尿蛋白結果作判讀的敏感度約80%,有大幅上升。研究顯示,新試紙爲更可信的早期診斷初期腎臟病變篩檢疾病之工具。 |
| 英文摘要 | A slight increase in urinary albumin level could be an advanced indicator of early stage nephropathy. The aim of this study was to detect the presence of albumin adjusted by creatinine using a dipstick to test urine samples from 301 patients with nephropathy. The dipstick method can also be used to calculate the protein-to-creatinine ratio (P/C ratio) as a valuable index for eliminating false positive or false negative protein reports, which are often caused by abnormal sample concentration variation. The results showed the test data for the dipstick show good agreement with the quantitative measurements of protein, creatinine and P/C ratio. The P/C ratio obtained by the dipstick showed a sensitivity of 98% compared with the protein-only results of 80% in diagnosis of clinical proteinuria/albuminuria. In conclusion, the dipstick is a reliable and practical screening tool for diagnosing the early stage of nephropathy. |
本系統中英文摘要資訊取自各篇刊載內容。