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| 題 名 | 促進中醫多元發展計畫--分項計畫3:光針治療海洛因成癮者的隨機對照試驗=Effect of Light Needle in the Treatment of Heroin Addicts: A Randomized-controlled Trial |
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| 作 者 | 胡文龍; | 書刊名 | 中醫藥年報 |
| 卷 期 | 14 2025.12[民114.12] |
| 頁 次 | 頁(2)1-(2)55 |
| 分類號 | 413.912 |
| 關鍵詞 | 光針; 海洛因成癮者; 美沙冬治療; 中醫學; Light needle; Heroin addicts; Methadone treatment; Traditional Chinese medicine; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 研究目的: 探討應用光針輔助治療海洛因成癮者的療效,建立光針參與戒毒治療模式。 研究方法: 本研究為隨機對照研究,於成癮戒治中心收案 100 位年滿 20 歲海洛因成癮患者(111 年 30 位,112 年 70 位),隨機分配至實驗組(光針)或對照組(無雷射輸出的光針), 實驗組施以光針治療,為期 4 週,共治療 12 次。對照組施以偽光針治療(無雷射輸出)。 治療前後驗尿(海洛因),個案自填上週海洛因使用次數或天數,個案使用視覺類比量表 (Visual Analogue Scales)自填上週對海洛因的渴求分數/拒絕再用海洛因(0-10 分),個案自 填生活品質量表(Short Form-12v2),量測脈象及心律變動性分析(heart rate variability)。使 用獨立樣本 T 檢定(independent t test)和卡方檢定(chi-square test)評估和比較實驗組和 對照組之間的患者基線特徵。獨立樣本 T 檢定用於比較兩組之間的差異。配對 t 檢驗 (paired t-test)用於兩組內的比較。 研究結果: 治療後的尿中嗎啡陽性率及上周使用海洛因的次數或天數,兩組皆無顯著差異。兩 組上周對海洛因的渴求皆有所下降(-0.60,P=0.132 vs. -0.67,P=0.470),調整差異為 0.07 (95% CI -1.97~2.11;P=0.946)。兩組上周拒絕使用海洛因的情況皆有所增加(0.33, P=0.547 vs. 0.67,P=0.433),調整後差異為 -0.33(95% CI -2.36~1.69;P=0.738)。SF-12v2 健康調查顯示,對照組有顯著的活力減退(p= 0.007)。心率變異性分析顯示,兩組之間沒 有顯著差異。 討論與結論: 光針結合傳統針灸與低強度雷射治療的效果。本研究顯示光針可降低海洛因成癮者 對海洛因的渴求,減緩活力的衰退,但由於樣本數不足而未達統計顯著差異。建議繼續 提供足夠經費執行光針輔助戒毒之本國多中心隨機對照研究,收案足夠樣本數(100 例), 建立有力實證,使光針輔助戒毒成為常規治療。 |
| 英文摘要 | Objective: To investigate the effect of adjuvant light needle in the treatment of heroin addicts and establish the model of light needle treatment for drug addiction. Methods: A randomized-controlled study is conducted. One hundred heroin addicts older than 20 years old enrolled from Addiction Treatment Center, 30 subjects in year 1 and 70 subjects in year 2, are randomly allocated to experimental or control group. Subjects in experimental group are treated with light needle on the wrist pulse (Cunkou) 12 times within 4 weeks. Subjects in the control group received a sham light needle treatment, without any laser output. Outcome measurements include check of urine morphine, report of the subjects’ times or days of heroin use, self-filling Visual Analogue Scales of heroin craving / refusal of heroin use (0-10 points) during last week, report of the subjects’ quality of life using Short Form-12v2, and record of the subject’s pulse diagnosis and heart rate variability before and after treatment. The independent t-test and chi-square test were used to evaluate and compare the baseline patient characteristics between the experimental and control groups. The independent t-test was used to compare the differences between the two groups. Paired t-test was used for comparisons in the two study groups. Results: There were no significant differences between the two groups in the post-treatment urinary morphine positivity rate and the episodes or days of heroin use in the previous week. Heroin cravings decreased in both groups in the previous week (-0.60, P=0.132 vs. -0.67, P=0.470), an adjusted difference of 0.07 (95% CI -1.97~2.11; P=0.946). Heroin refusal increased in the previous week in both groups (0.33, P=0.547 vs. 0.67, P=0.433), an adjusted difference of -0.33 (95% CI -2.36~1.69; P=0.738). The post-treatment SF-12v2 health survey showed a significant decrease in vitality in the control group (p=0.007). Heart rate variability analysis showed no significant difference between the two groups. Discussion and Conclusion: Light needle integrated the effects of traditional acupuncture and low-level laser therapy. This study shows that light needle can decrease heroin cravings and slow down the decline of vitality in heroin addicts, but the difference did not reach statistical significance due to insufficient sample size. It is recommended to continue to provide sufficient funds to carry out the multi-center randomized controlled study of adjuvant light needle in drug addiction treatment in Taiwan, to enroll sufficient samples (100 cases), to establish solid evidence, and to make adjuvant light needle therapy as a routine treatment for drug addiction. |
本系統中英文摘要資訊取自各篇刊載內容。