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來源資料
頁籤選單縮合
| 題 名 | 光針治療海洛因成癮者的隨機對照試驗=Effect of Light Needle in the Treatment of Heroin Addicts: A Randomized-controlled Trial |
|---|---|
| 作 者 | 胡文龍; | 書刊名 | 中醫藥年報 |
| 卷 期 | 13 2024.10[民113.10] |
| 頁 次 | 頁(8)1-(8)76 |
| 分類號 | 413.912 |
| 關鍵詞 | 光針; 海洛因成癮者; 美沙冬治療; 中醫學; Light needle; Heroin addicts; Methadone treatment; Traditional Chinese medicine; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 目的: 探討應用光針輔助治療海洛因成癮者的療效,建立光針參與戒毒治療模式。 方法: 本研究為隨機對照研究,於兩醫學中心收案 107 位年滿 20 歲海洛因成癮患者,隨機 分配至實驗組(光針)或對照組(無雷射輸出的光針),實驗組施以光針治療,為期 4 週, 共治療 12 次。對照組施以偽光針治療(無雷射輸出)。治療前後驗尿(海洛因),個案自填上 週海洛因使用次數或天數,個案使用視覺類比量表(Visual Analogue Scales)自填上週對海 洛因的渴求分數/拒絕再用海洛因(0-10 分),個案自填生活品質量表(Short Form-12v2),量 測脈象及心律變動性分析(heart rate variability)。使用獨立樣本 T 檢定(independent t test)和 卡方檢定(chi-square test)評估和比較實驗組和對照組之間的患者基線特徵。獨立樣本 T 檢定用於比較兩組之間的差異。配對 t 檢驗(paired t-test)用於兩組組內的比較。 結果: 治療後實驗組的尿中嗎啡陽性率、上周使用海洛因的次數或天數及上周對海洛因的 渴求皆顯著下降,兩組之間的校正後差異為分別為 -0.19(95% CI -0.35 ~ -0.03;P=0.020)、 -0.81(95% CI -1.36 ~ -0.27;P=0.004)、-1.08(95% CI -2.01 ~ -0.15;P=0.024)。兩組上周拒絕使用海洛因的調整後差異為 1.13(95% CI 0.00 ~ 2.25;P=0.049)。SF-12v2 健康調查 及心率變異性分析顯示,兩組之間沒有顯著差異。 討論與結論: 光針結合傳統針灸與低強度雷射治療的效果,寸口光針應用具有血管光生物調節的 作用。本研究顯示經過 4 週的光針輔助治療鴉片類藥物使用障礙患者,有效降低尿中嗎 啡陽性率、海洛因使用次數及對海洛因的渴求。我們建議寸口光針作為美沙冬治療鴉片類 藥物使用障礙患者的輔助治療。 |
| 英文摘要 | Objective: To investigate the effect of adjuvant light needle in the treatment of heroin addicts and establish the model of light needle treatment for drug addiction. Methods: A randomized-controlled study is conducted. One hundred and seven heroin addicts older than 20 years old enrolled from two medical centers are randomly allocated to an experimental or control group. Subjects in the experimental group are treated with a light needle on the wrist pulse (Cunkou) 12 times within 4 weeks. Subjects in the control group received a sham light needle treatment without any laser output. Outcome measurements include a check of urine morphine, a report of the subjects’ times or days of heroin use, self-filling Visual Analogue Scales of heroin craving or refusal of heroin use (0–10 points) during the last week, a report of the subjects’ quality of life using Short Form-12v2, and a record of the subject’s pulse diagnosis and heart rate variability before and after treatment. The independent t-test and chi-square test were used to evaluate and compare the baseline patient characteristics between the experimental and control groups. The independent t-test was used to compare the differences between the two groups. A paired t-test was used for comparisons in the two study groups. Results: After treatment, the positive rate of urinary morphine, the episodes or days of heroin use, and the heroin craving in the previous week were all significantly reduced in the experimental group. The adjusted differences between the two groups were -0.19 (95% CI -0.35 ~ -0.03; P=0.020), - 0.81 (95% CI -1.36 ~ -0.27; P=0.004), and -1.08 (95% CI -2.01 ~ -0.15; P=0.024). The adjusted difference in refusal of heroin use in the previous week between the two groups was 1.13 (95% CI 0.00 to 2.25; P = 0.049). There were no significant differences between the two groups in the post-treatment SF-12v2 health survey and heart rate variability analysis. Discussion and Conclusion: Light needle combines the effects of traditional acupuncture and low-intensity laser therapy. The application of light needle at Cunkou has the effect of vascular photobiomodulation. This study shows that after 4 weeks of light needle-assisted treatment for patients with opioid use disorder, it can effectively reduce the positive rate of urinary morphine, the frequency of heroin use, and the desire for heroin. We recommend light needle at Cunkou as an adjunctive treatment with methadone in patients with opioid use disorder. |
本系統中英文摘要資訊取自各篇刊載內容。