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題 名 | 血友病患者之舌癌治療--病例報告=Hemophilia Patient with Tongue Cancer--A Case Report |
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作 者 | 蘇昶瑋; 陳裕豐; 許經偉; 林佩瑾; 林裕珉; 邱日宥; 柯政全; 許瀚仁; 楊家福; 陳中和; 陳俊明; 高郁勛; 林珮瑾; | 書刊名 | 臺灣口腔顎面外科學會雜誌 |
卷 期 | 30:2 2019.06[民108.06] |
頁 次 | 頁116-124 |
分類號 | 416.89 |
關鍵詞 | 血友病; 第八因子; 口腔癌; Hemophilia; Factor VIII; Oral cancer; |
語 文 | 中文(Chinese) |
中文摘要 | 血友病患者為體內凝血因子缺乏,一旦組織受到創傷引起出血,無法進行正常凝血機制,嚴重者會危及生命,因此這族群病患除日常生活需避免外傷發生,在需接受外科手術治療時更要特別注意;本報告病例為45歲血友病男性罹患右舌惡性鱗狀細胞癌,臨床分期第三期(cT1N1M0),經會診本院特殊血液防治中心評估,配合第八凝血因子注射,完成右舌病灶廣泛性切除手術與右頸淋巴廓清手術,治療期間無出血不止合併症,術後病理報告為第一期(pT1N0M0),持續門診追蹤。然而在術後10個月與1年11個月發現右頸淋巴轉移,均配合第八凝血因子注射將病灶手術切除,並安排術後放射線治療與化學治療,目前仍穩定追蹤中;口腔癌的治療以手術為主,對於凝血功能異常的病患,直接的影響就是傷口無法有效止血,不僅影響手術視野、術後傷口癒合,但在審慎評估並配合相關凝血因子補充,這類病患也能得到有效治療。 |
英文摘要 | Hemophilia is a disease of genetic disorder related to insufficient coagulation factors, which interfere the normal coagulation mechanism. Those patients will bleed longer after trauma or surgery. Without proper management, the patients will encounter life-threaten risk. Therefore, it is important to avoid any body injury in patients' daily life. We reported a 45-year-old male hemophilia A patient with right tongue squamous cell carcinoma (cT1N0M0 stage III). After Factor VIII transfusion, the operation of wide excision and right neck dissection was performed. The patient recovered well without any hemostasis complications. The pathologic report was pT1N0M0 stage I. Unfortunately, metastasis of right neck lymph node was noticed during regular follow-up on 10 months, and 1 year 11 months after operation. The lymphadenectomy was done smoothly with factor VIII transfusion. The adjuvant chemotherapy and radiotherapy was arranged after the surgery. The patient recovered well during regular follow up. It is challenging for surgeons to operate for abnormal coagulation function patients. With detailed evaluation of patient's systemic condition and appropriate transfusion of factor VIII, the hemophilia patients can obtain ideal treatment and recover well. |
本系統中英文摘要資訊取自各篇刊載內容。