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| 題 名 | 兒科加護病房癲癇重積症藥物治療=Analysis of the Drug Treatment for Status Epilepticus in the PICU |
|---|---|
| 作 者 | 王嘉珍; 戴慶玲; 徐美欣; | 書刊名 | 藥學雜誌 |
| 卷 期 | 34:3=136 2018.09[民107.09] |
| 頁 次 | 頁54-61 |
| 分類號 | 418.21 |
| 關鍵詞 | 癲癇重積症; 抗癲癇藥物; 兒科加護病房; Status epilepticus; Antiepileptic drugs; Pediatric intensive care unit; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 目的:回溯分析兒科加護病房抗癲癇藥物療效和藥物不良反應。 方法:回溯分析2009年1月至2015年12月間,兒科加護病房癲癇重積症病人電子病 歷記錄。研究結果以百分比和平均值±標準差 (mean ± SD) 表示,P值 < 0.05代表具有 統計上之差異。 結果:符合本研究納入條件者共101位,「急性症狀性」病因在頑固性/超頑固 性癲癇重積症者明顯高於癲癇重積症者 (p < 0.003)。Phenobarbital 最常當作第二線 治療藥物。Midazolam 連續靜脈輸注對於頑固性癲癇重積症有很好的療效。三位病 人於治療期間出現藥物不良反應,二位疑似 phenobarbital 引起皮膚紅疹,一位疑似 carbamazepine 或 phenytoin 引起伴隨嗜酸性白血球增多全身過敏反應 (drug reaction with eosinophilia and systemic symptoms;DRESS)。 結論:Phenobarbital 是兒科加護病房中最常使用於治療癲癇重積症的藥物,併用 二種抗癲癇藥物,能夠有效地終止多數癲癇重積症發作。 |
| 英文摘要 | Objective: The aim of this retrospective study was to evaluate the antiepileptic drugs with regard to the efficacy and adverse drug reactions in the Pediatric Intensive Care Unit (PICU). Method: This was a retrospective analysis of electronic medical records of the children with SE who were admitted to the PICU of our hospital from January 2009 to December 2015. The study results are expressed as a percentage and mean ± SD. The P values <.05 were considered as statistically significant. Results: During the study period, 101 patients were enrolled. Among them, an acute symptomatic etiology showed significantly more prevalent in patient with RSE/ super-RSE than those with SE (p < 0.003). Phenobarbital is commonly used as a second-line AEDs for this treatment. The midazolam by continuous intravenous infusion has shown a good effect on RSE. Three patients developed adverse drug reactions during treatment, two of them were suspected phenobarbital-caused skin rash, and the other one was suspected carbamazepine or phenytoin-caused DRESS. Conclusions: Phenobarbital was the most commonly used anticonvulsant to treat SE patients in the PICU. The combination therapy of two AEDs can effectively terminate SE. |
本系統中英文摘要資訊取自各篇刊載內容。