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頁籤選單縮合
| 題 名 | 圓禿治療的新契機=Emerging Opportunity of Therapy in Alopecia Areata |
|---|---|
| 作 者 | 郭廷濠; 張華景; | 書刊名 | 藥學雜誌 |
| 卷 期 | 34:1=134 2018.03[民107.03] |
| 頁 次 | 頁39-44 |
| 分類號 | 415.7752 |
| 關鍵詞 | 圓禿; 掉髮; CD8毒殺型T細胞; JAK抑制劑; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 圓禿是自體免疫導致毛髮暫時性掉落的常見疾病,其病生理機制十分多元且複 雜,目前多認為與 CD8毒殺型T細胞突破毛囊的免疫特權區域有關,除現行治療所使 用的類固醇、局部刺激劑、局部免疫治療、光化學治療及免疫抑制劑外,基於對圓禿 致病機轉的進一步了解,已發現許多促進發炎的訊號皆仰賴 JAK- STAT 的訊息傳遞路 徑,而 JAK 抑制劑已在近來許多研究中顯示其對於圓禿治療的效果,因此 JAK 抑制 劑被認為是未來使用於圓禿治療的新契機。 |
| 英文摘要 | Alopecia areata (AA) is an autoimmune-related transient non-scarring hair loss. Multiple factors are involved in the pathophysiology of AA. To date, many studies have suggested that breakdown of hair follicle immune privilege with CD8+ T lymphocytes infiltration plays an important role in AA. Current treatment includes corticosteroids, topical irritants, topical immunotherapy, photochemotherapy, and immunosuppressants. Growing evidence suggests that JAK inhibitors are efficacious in several autoimmune diseases, and it also showed favorable results for AA treatment in recent studies. Hence, JAK inhibitors offer promise for future treatment of AA. |
本系統中英文摘要資訊取自各篇刊載內容。