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題名 | 一個新穎、高效的C肝病毒蛋白酶抑制劑:TG-2349(伏拉瑞韋)=A Novel and High Potent HCV Protease Inhibitor: TG-2349 (Furaprevir) |
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作者姓名(中文) | 陳治明; 林助強; 張俐雯; 蔡承遠; 許明珠; | 書刊名 | 臺灣醫學 |
卷期 | 21:6 2017.11[民106.11] |
頁次 | 頁595-602 |
專輯 | C型肝炎新進展 |
分類號 | 415.5332 |
關鍵詞 | 慢性C型肝炎; 直接抗病毒藥物; 蛋白酶抑制劑; 治療結束後第12週達到持續病毒學抑制反應; Chronic hepatitis C; Direct-acting antiviral agent; Protease inhibitor; SVR 12; |
語文 | 中文(Chinese) |
中文摘要 | TG-2349(通用名:伏拉瑞韋)是一個醯基磺醯胺類的新型C肝病毒蛋白酶抑制劑,對6種不同基因型的蛋白酶均有良好的抑制活性,也能有效壓制常見的抗藥性突變株。已完成的臨床I期及臨床II期試驗顯示,TG-2349有良好的安全性與耐受性;每日服用一劑,血中藥物濃度遠高過抑制病毒的程度;連續服用3天後,基因型第1a、2、4、或6型患者體內病毒下降量達2.8-3.6 log。對第1b亞型(佔亞洲病人60%以上)下降量更高達4.4 log。當與C肝標準療法(長效型干擾素+雷巴威林)合併時,對基因型1b患者的治療時間可以縮短到12週,療效提升至90%(SVR12)以上,證實了TG-2349是一個新穎且具高療效的C肝病毒抑制劑。臨床開發包含TG-2349與其他DAA共用的全口服療法也正在積極進行中。 |
英文摘要 | TG-2349 (INN name Furaprevir) is a novel sulfonamide class of HCV NS3/4A protease inhibitor. It is potent against both wild type and mutant proteases across genotype 1 to 6 in vitro. TG-2349 is generally safe and well tolerated in phase I/II clinical studies to date. PK results supported QD dosing. In a proof-of-concept trial against treatment-naive patients with different HCV genotypes, 3-day dosing of TG-2349 demonstrated HCV viral load reductions of 2.8 - 3.6 log in genotypes 1a/2/4/6 subjects. Reductions of 4.4 log were achieved in GT-1b subjects, which consists of >60% of Asian HCV patients. Total treatment durations can be reduced from over 24 weeks to 12 weeks when combining TG-2349 with the current SOC peginterferon/ribavirin. SVR24 of >90% was observed in Taiwanese naive GT-1b subjects. Development of TG-2349-containing all-oral, IFN-free HCV treatments are underway. |
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