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題 名 | 甜蜜的脆弱:糖尿病與骨質疏鬆症之關聯性=Sweet and Fragile--Relationship between Diabetes and Osteoporosis |
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作 者 | 吳書婷; 陳擇穎; 蔡嘉仁; 陳榮福; | 書刊名 | 內科學誌 |
卷 期 | 28:2 2017.04[民106.04] |
頁 次 | 頁65-73 |
分類號 | 415.668 |
關鍵詞 | 糖尿病; 骨質疏鬆症; 骨折; 糖化終產物; Diabetes; Osteoporosis; Fracture; Advanced glycation end products; |
語 文 | 中文(Chinese) |
中文摘要 | 隨著我國逐漸進入高齡化社會以及現代生活型態改變,糖尿病和骨質疏鬆症患者日益增多。相當多的研究在探討糖尿病和骨質疏鬆症兩者之間的關係,根據研究指出糖尿病患者有相對較高的骨折風險,其中的病理生理機制部分了解,但仍無確切的定論。目前評估骨折風險的工具在糖尿病患者身上相對容易低估。仍有眾多因子會增加並且影響糖尿病患的骨折風險。「糖化終產物- 糖化終產物受器- 氧化壓力軸」近年來被提出會降低骨骼密度進而增加糖尿病患者的骨骼脆度。其他像是糖尿病的併發症:視網膜病變、神經病變、以及血管病變也都與骨折風險相關。近年研究證實,有些降血糖藥物亦可能會影響骨骼代謝、增加骨折的風險。糖尿病患者在治療骨質疏鬆症的策略與非糖尿病患者應當相同。 |
英文摘要 | As the number of older adults in the population rises and lifestyle changes, the prevalence of diabetes and osteoporosis is expected to increase. Substantial studies have investigated the relationship between diabetes and osteoporosis. There is growing evidence indicate the diabetes mellitus is associated with greater fracture risk, and the pathophysiology of diabetic bone disease is partially understood. Currently, standard diagnostic tools for fracture prediction tend to underestimate the fracture risk of patients with diabetes. Contributing factors to increased fracture risk in diabetes is complicated and multifactorial. The "AGEs-RAGE-oxidative stress system" is one of pathophysiological role in decreased BMD and increased bone fragility in diabetes. Complications of diabetes, such as retinopathy, neuropathy, and vascular complications are also related to the risk of fracture. Several studies have described that antidiabetic drugs are indispensable for glycemic control, and they also modulate the bone metabolism and fracture risk. Strategies to prevent and treatment osteoporosis in patients with diabetes are the same as for those without diabetes. |
本系統中英文摘要資訊取自各篇刊載內容。