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題 名 | Statin與TZD對第二型糖尿病骨質的影響=Effects of Statin and TZD on Bone in Type 2 Diabetes |
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作 者 | 顧家恬; 彭瓊琿; | 書刊名 | 耕莘學報 |
卷 期 | 6 2008.06[民97.06] |
頁 次 | 頁55-64 |
分類號 | 418.271 |
關鍵詞 | 第二型糖尿病; 骨質疏鬆症; 骨折; TZD; Statin; Type 2 diabetes; Osteoporosis; Bone fracture; |
語 文 | 中文(Chinese) |
中文摘要 | Thiazolidinediones (TZD) 是目前常用的第二型糖尿病用藥,其除升高胰島素敏感性外,更有抗炎、降腦等多 重效果。然而臨床試驗卻發現TZD易造成女性糖尿病患骨折。事實上,儘管糖尿病患者擁有較高的骨質密度 (bone mineral density, BMD),其本身即可能因神經、血管與代謝障礙而導致骨質問題。另一方面,Statin為降脂藥物具抗氧化、抗進階糖化產物 (advanced glycation end product, AGE) 等作用,其可防治包含糖尿病所引發的心血管疾患,近年來又發現其似乎具有保護骨質的能力,然而有關statin與TZD併用於骨質的影響卻尚無論述。本文將探討TZD與statin對於糖尿病患骨質的影響,提出合併使用TZD與statin的合理性,其除可預防第二型糖尿病的心血管事件外,可能也得以保護骨質、降低骨折風險,尤其針對女性病患而言。 |
英文摘要 | Thiazolidinediones (TZDs) are one kind of anti-glycemic drugs for type 2 diabetes. In addition to increasing insulin sensitivity. TZDs have been shown to exert their multiple effects on anti-inflammation and lipid-lowering. However. recent clinical trials suggest TZDs are associated with bone loss or fracture in older diabetic women. Diabetic women exhibit more rapid bone loss despite the higher baseline bone mineral density. The higher fracture risk of type 2 diabetes may be associated with neural and vascular complications. or the fragile bone structure. on the other hand. statins have been well-recognized as an effective lipid-lowering drug. They were found to prevent the cardiovascular disorders through anti-oxidation and antiadvanced glycation end product generation on diabetic patients. Recently, statins were shown to exert protective effects on bone. The impact of combination use of statins and TZDs on bone however has never been addressed. In the present article, we review from the literature about the possible impact of TZDs and statins on bone. Considering the advantages of statins and TZDs in treating type 2 diabetes regarding their cardiovascular protection and glycemic control improvement, we hypothesize that the concomitant use of statins and TZDs might also prevent against bone complications of type 2 diabetes or induced by TZDs, especially for older diabetic women. |
本系統中英文摘要資訊取自各篇刊載內容。