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頁籤選單縮合
題名 | Genome-wide Association Study of Body Composition Traits in Chicken=雞體組成性狀全基因組關聯性分析 |
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作者 | 練慶儀; 吳詩雯; 譚發瑞; 陳志峰; | 書刊名 | 中國畜牧學會會誌 |
卷期 | 45:4 2016.12[民105.12] |
頁次 | 頁285-299 |
分類號 | 437.71 |
關鍵詞 | 體組成; 雞; 基因組關聯性分析; 單一核苷酸多型性; Body composition; Chicken; Genome-wide association study; Single nucleotide polymorphism; |
語文 | 英文(English) |
中文摘要 | 產肉量為家禽產業的重要經濟性狀。本研究旨在於尋找與雞隻體組成性狀顯著相關之單一核甘酸多型性( signal nuclide polymorphism, SNP)效應。動物族群採用台灣土雞 L2 品系(選拔第 12、14 週齡雞冠面積及第 40 週齡產蛋量)與洛島紅 R-試驗品系(選拔低飼料採實殘差)進行雜交之子二代進行試驗。 157 隻 F2 代公雞於 23 週齡時屠宰,收集 21 個體組成表型性狀與由 Illumina 60K iSelect SNP晶片鑑定取得之 SNP基因型資料後,利用全基因組關聯性分析(genome-wide association study, GWAS)找尋性狀與 SNP效應間的關聯性。此外,候選基因的功能性解析運用於定義染色體區間內相關基因與其對應之 SNP的功能。全基因組關聯性分析結果顯示,有 23 個 SNP效應達 5% Bonferroni 基因組顯著水準( P < 6.2×10-6),其與腹脂、羽毛、腳、砂囊、腸、胸皮、及睪丸重量等體組成性狀具關連性,另亦有 225 個 SNP效應達建議顯著水準( P < 1.24×10-4)。此外,本研究亦找出許多與雞隻體組成相關之潛在候選基因,如: SOX10。利用基因組關聯性分析可尋找與性狀相關聯的 SNP效應及候選基因。未來可利用數量性狀基因座定位(quantitative trait locus mapping, QTL mapping)分析,以精確定義與雞隻體組成性狀相關的 QTLs。 |
英文摘要 | Meat yield is an important economic trait for poultry production. The present study aims at the identification of significant single nucleotide polymorphism (SNP) effect associated with body composition traits in chickens. An F2 population was produced by crossing the Taiwan Country Chicken L2 line (selected for body weight, size of comb area and egg production) with the experimental line of Rhode Island Red layer R- (selected for low residual feed consumption). A total of 157 F2 males were genotyped with the 60K Illumina iSelect SNP chip. Genome-wide association study (GWAS) was performed for 21 body composition traits measured at 23 weeks of age. Furthermore, functional annotation of causative genes was used to identify relevant genes and corresponding SNPs within chromosomal regions. Whole genome linkage analysis led to identifying 23 SNP effects for 7 carcass traits (abdominal fat, feather, feet, gizzard, intestine, breast skin, and testis weight) with 5% Bonferroni genome-wide significance (P < 6.20×10-6), and a total of 225 SNP effects reached suggestive significance (P < 1.24×10-4). Possible candidate genes such as SOX10 for body composition traits were identified. Genome-wide association study made it possible to identify amounts of SNPs associated with relevant genes for recorded traits. Quantitative trait locus (QTL) mapping should be applied for following analysis to confirm the association between QTLs and measured traits in chicken. |
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